超敏C反应蛋白与急性脑梗死关系的探讨

目的 探讨C反应蛋白(CRP)与急性脑梗死(ACI)及其预后的关系.方法 对86例ACI患者及88课题项目:广州市医药卫生科研基金课题(编号:2006-YB-214)例年龄相匹配的非脑梗死(NS)患者进行颈动脉超声各项指标及动脉硬化各项危险因素检测.结果 ACI组与Ns组比较,CRP(P<0.01)和LDL(P<0.05)水平明显升高;颈动脉斑决组与无斑块组比,CRP水平增高(P<0.05).颈动脉斑块组与无斑块组比较,内中膜厚度(IMT)增加(P<0.01),NS组颈动脉IMT厚度差异无统计学意义(P>0.0 5),ACI组,IMT厚度差异明显(P<0.05).与NS组比较,ACI组中等程度狭窄更常见(P<0.0 5).结论 CRP增高是导致颈动脉硬化粥样斑块形成的重要标志物,因此,CRP可以作为预测ACI发展和预后的指标.

Correlation between the C-reactive protein and acute cerebral infarotion

Objective To investigate the roles of C-reactive protein(CRP)in the pathogenesis of acute cerebral infarction (ACI) and its relationship with prognosis.Methods 86 ACI patients and 88 age-matched non-stroke cases(NS) were checked by an invasive color ultra-sonography on the carotid arteries. The common risk factors of atherosclerosis (AS) and the value of CPR were associated with ultrasonic findings.Results Compared with the NS group, a significantly increased level of CRP (P <0.01) and LDL (P <0.05) were found in the ACI group.CRP levels (P <0.05) were higher in the plaque group than those in the non-plaque group.Compared with the non-plaque group ,a thicker intima-media thickness(IMT) of carotid artery (P<0.01) was found in the plaque group. Compared with the NS group the IMT of carotid artery had no statistic difference (P >0.05), but the IMT of intracarotid artery was significantly different (P<0.05) in the ACI group. Compared with the NS group the midrange stegnosis was more common (P<0.01) in the ACI group.Conclusion The level of CRP may play an important role and be an important marker in the formation of atherosclerotic plaque.So CRP is an suggested index to predict the development and prognosis of ACI.