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Molekulare Mechanismen der Embryoimplantation im Endometrium |
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| Authors: | Dr A Schanz A Hess A Shahin J Hirchenhain G Griesinger J S Krüssel |
| Institution: | 1. Universit?ts-Frauenklinik, Heinrich-Heine-Universit?t Düsseldorf, 4. Universit?tsfrauenklinik, Heinrich-Heine-Universit?t Düsseldorf, Moorenstra?e 5, 40225, Düsseldorf 2. Stanford University, Palo Alto, Kalifornien, 3. Universit?tsfrauenklinik, Universit?tsklinikum Schleswig-Holstein, Campus Lübeck, |
| Abstract: | Human Reproduction is a very complex and surprisingly inefficient process. The embryo development and the generation of a receptive endometrium needs an exact timing and synchronization. Understanding the factors involved in preimplantation embryo development and embryo-maternal interaction and implantation is crucial for improving success rates in reproductive medicine. The purpose of the present review is to describe briefly the function of adhesion- and hormonal factors, cytokines, growth factors and metalloproteinases. A better understanding of the molecular mechanisms of implantation will be responsible for the improvement of clinical and therapeutical management of sterility, infertility and contraception. |
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