Erythrokinetic Studies in Severe Bone Marrow Failure of Diverse Etiology

1. Erythropoiesis was studied in seven patients with refractory anemia.

2. In all seven patients the total red cell volume was low and the plasmavolume elevated.

3. The serum iron was elevated and iron binding protein saturated in sixof seven patients.

4. The T for clearance plasma Fe⁵⁹ was decreased in one, normal in two,and increased in four patients.

5. The red cell iron turnover was decreased in six of seven patients.

6. Radioiron accumulated in liver and spleen.

7. Red cell life span was difficult to measure but probably shortened.

8. Androgen therapy in two cases was ineffective, and was associated witha slight effect in one patient.

Submitted on April 18, 1961 Accepted on September 14, 1961