肝积颗粒联合肝动脉化疗栓塞术治疗中晚期肝癌近期疗效研究

目的:观察肝积颗粒联合肝动脉化疗栓塞术治疗中晚期肝癌近期疗效。方法:将80 例中晚期肝癌患者按照随机数字表分为治疗组和对照组,每组40 例。对照组予以肝动脉化疗栓塞术治疗,治疗组在肝动脉化疗栓塞术基础上服用肝积颗粒,1剂/d。术后3个月评价近期疗效,观察ALT、AST、GGT、TBIL、ALB等肝功能指标,以及AFP、KPS评分、不良反应发生情况。结果:治疗组有效率为65.0%,对照组分别为42.5%,治疗组近期疗效优于对照组(P<0.05)。组内术后3 个月与治疗前比较,两组ALT、AST、GGT、TBIL水平明显下降,ALB水平明显上升(P<0.05)。术后3个月与对照组比较,治疗组ALT、AST、GGT、TBIL明显下降、ALB水平明显升高,相比较差异均有统计学意义(P<0.05)。组内术后3个月与治疗前相比,两组AFP 水平下降(P<0.05),KPS 水平升高(P<0.05); 组间治疗后比较,AFP、KPS 差异有统计学意义(P<0.05)。治疗组、对照组总体不良反应发生率分别为5.0%、20.0%,比较差异有统计学意义(P<0.05)。结论:肝积颗粒联合肝动脉化疗栓塞术治疗中晚期肝癌,可提高近期疗效,改善患者生存质量,减少不良反应。

Study on the short-term efficacy of Ganji granule combined with transcatheter arterial chemoembolization in the treatment of advanced liver cancer

Objective:To observe the short-term efficacy of Ganji granules combined with transcatheter arterial chemoembolization in the treatment of advanced liver cancer.Methods:80 patients with advanced liver cancer were randomly divided into treatment group and control group,with 40 cases in each group.The control group was treated with transcatheter arterial chemoembolization,and the treatment group received Ganji granules one dose per day,on the basis of transcatheter arterial chemoembolization.The short-term efficacy was evaluated 3 months after operation,and changes in liver function-related laboratory indicators ALT,AST,GGT,TBIL,ALB,AFP,KPS score,and adverse reactions were observed.Results:The effective rate was 65.0% in the treatment group and 42.5% in the control group.The short-term efficacy of the treatment group was better than that of the control group(P<0.05).Compared with before treatment,3 months after operation in the group,the levels of ALT,AST,GGT,TBIL in the treatment group were significantly decreased,and the levels of ALB were significantly increased(P<0.05).Compared with the control group at 3 months after operation,the differences in ALT,AST,GGT,TBIL,and ALB in the treatment group were statistically significant(P<0.05).Compared with before treatment,the AFP level in the two groups decreased(P<0.05)and the KPS level increased(P<0.05)in the 3 months after the operation.There was statistically significant difference in AFP and KPS between groups after treatment(P<0.05).The overall adverse reaction rates of the treatment group and the control group were 5.0% and 20.0%,respectively.There was statistically significant difference in the overall adverse reaction rates between the groups(P<0.05).Conclusion: Ganji granule combined with transcatheter arterial chemoembolization can improve the short-term efficacy,improve the quality of life of patients,and reduce adverse reactions.