新型冠状病毒肺炎患者肝功能异常的相关临床分析

目的　探讨新型冠状病毒肺炎（COVID-19）患者肝功能异常的相关性因素。方法　回顾性分析湖南省岳阳市 第一人民医院2020 年1~3 月收治的新型冠状病毒（SARS-CoV-2）感染患者80 例，根据肝功能情况分为肝功能异常 组45 例，对照组35 例，对其进行病例对照研究，选择与肝损伤有关指标进行单因素及多因素分析，探讨COVID-19 患者肝功能异常的发生机制。结果　研究显示肺炎严重程度是COVID-19 患者发生肝损伤的主要危险因素（P=0.009， OR=3.826，95%CI 1.388~10.544），而基础疾病、炎症因子水平与COVID-19 患者出现肝损伤无统计学相关性（P>0.05）。 结论　COVID-19 患者发生肝功能损害与病情进展密切相关，临床医生诊治患者时，应当遵从早发现、早治疗的原则， 避免造成肝脏进一步损伤，改善患者预后。

Clinical Analysis of Abnormal Liver Function in Patients with New Coronavirus Pneumonia

Objective　To explore the related factors of abnormal liver function in patients with COVID-19. Methods　A retrospective analysis of 80 patients with SARS-CoV-2 infetion admitted to the First People’s Hospital of Yueyang from January 1 to March 30, 2020, was carried out. According to the liver function, 45 cases entered abnormal liver function group and 35 cases entered control group. A case control study was conducted to explore factors related to abnormal liver function in patients with new pneumonia. Results　This study showed that the severity of pneumonia was a risk factor for liver injury in patients with COVID-19(P=0.009, OR=3.826, 95%CI 1.388 ~ 10.544), while the basic diseases and inflammatory factors level had nostatistical correlation withpatients with theliver injury of the patients with COVID-19 (P>0.05). Conclusion　The liver injury in patients with COVID-19 was closely related to the progression of the pneumonia. When treating patients, clinicians should follow the principles of early detection and early treatment to avoid further damage to the liver and to improve patients’ prognosis.