代谢综合征与子宫内膜癌

代谢综合征是多种代谢异常的集合,胰岛素抵抗是其病理生理学基础.流行病学研究显示,不但代谢综合征是胰岛素抵抗的危险因素,并且与代谢综合征相关的肥胖、糖尿病以及高血压等以胰岛素抵抗为共同特征的疾病都是子宫内膜癌的危险因素.胰岛素抵抗形成后,循环中胰岛素水平升高,胰岛素可以直接地通过其信号传导通路的激活以及间接地通过升高雌激素水平而促进子宫内膜癌的发生、发展,并且在胰岛素抵抗形成过程中的某些脂肪因子也有可能同时促进了子宫内膜癌的发生、发展.由此推测,胰岛素抵抗是子宫内膜癌和代谢综合征之间的桥梁,积极控制胰岛素抵抗可能有益于代谢综合征相关的子宫内膜癌的预防和治疗.

Metabolic Syndrome and Endometrial Carcinoma

Metabolic syndrome contains several metabolic disorders with insulin resistance as its pathophysiological basis.Epidemiological studies show that not only metabolic syndrome,but also metabolic syndrome related obesity,diabetes and hypertension which characterized with insulin resistance are all risk factors of endometrial carcinoma.At the state of insulin resistance,circulating insulin levels will increase.As a result,insulin promotes the development of endometrial carcinoma directly through the activation of its signaling pathway and indirectly through the up-regulation of the blood estrogen levels.Moreover,in the development of insulin resistance,the development of endometrial carcinoma is probably promoted simultaneously by some adipocytokines.Taken together,insulin resistance is a bridge related endometrial carcinoma with metabolic syndrome.Treatment targeting insulin resistance may serve as therapeutical purpose for inhibiting the development of metabolic syndrome related endometrial carcinoma.