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| 川芎嗪对大鼠脑缺血再灌注损伤的作用 | |
| 引用本文： | 张景秋,赵喜庆,吉训明,石文建,汪萍,刘志强,董得宏.川芎嗪对大鼠脑缺血再灌注损伤的作用[J].临床误诊误治,2011,24(2):41-43. |
| 作者姓名： | 张景秋 赵喜庆 吉训明 石文建 汪萍 刘志强 董得宏 |
| 作者单位： | 1. 唐山,唐山市中医医院神经外科,河北,063000 2. 唐山,唐山市人民医院神经外科,河北,063000 3. 首都医科大学附属北京宣武医院介入中心,北京,100053 |
| 摘 要： | 目的探讨中药川芎嗪对大鼠脑缺血再灌注损伤的作用机制。方法选用雄性Wistar大鼠25只,随机分为正常对照组(n=5)、脑缺血再灌注组(n=6)、尼莫地平组(n=7)及川芎嗪组(n=7)。正常对照组不做任何处理;余3组采用改良Zea Longa线栓法建立可再通脑缺血模型,模型成功建立后,各组大鼠腹腔分别注射0.9%氯化钠注射液、尼莫地平、川芎嗪;于脑缺血3 h和再灌注后48 h分别行神经功能评分。再灌注后48 h后测定各组大鼠脑血流。处死后对脑缺血再灌注组、尼莫地平组及川芎嗪组大鼠进行TTC染色计算脑梗死体积,并测定缺血区线粒体超氧化物歧化酶(SOD)活性。结果缺血再灌注48 h后4组脑血流值两两比较差异均有统计学意义(P<0.01);尼莫地平组与川芎嗪组脑梗死神经功能恢复评分均低于给药前和缺血再灌注组,差异均有统计学意义(P<0.01),且川芎嗪组改善情况优于尼莫地平组(P<0.01);缺血再灌注各组大鼠脑梗死区相对体积组间两两比较差异均有统计学意义(P<0.05,P<0.01)。川芎嗪组大鼠脑组织线粒体SOD活性与其他缺血再灌注组比较差异均有统计学意义(P<0.01)。结论川芎嗪具有抗氧自由基作用,可修复脑缺血再灌注损伤。 |
| 关 键 词： | 川芎嗪 脑缺血 再灌注损伤 超氧化物歧化酶 大鼠 |
The Effects of Ligustrazine Against Cerebral Ischemic/Reperfusion Injury in Rats |
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| ZHANG Jing-qiu,ZHAO Xi-qing,JI Xun-ming,SHI Wen-jian,WANG ping,LIU Zhi-qiang,DONG De-hong.The Effects of Ligustrazine Against Cerebral Ischemic/Reperfusion Injury in Rats[J].Clinical Misdiagnosis & Mistherapy,2011,24(2):41-43. | |
| Authors: | ZHANG Jing-qiu ZHAO Xi-qing JI Xun-ming SHI Wen-jian WANG ping LIU Zhi-qiang DONG De-hong |
| Institution: | ZHANG Jing-qiu1,ZHAO Xi-qing2,JI Xun-ming3,SHI Wen-jian2,WANG ping2,LIU Zhi-qiang2,DONG De-hong2(1.Department of Neurosurgery,Tangshan Traditional Chinese Medical Hospital,Tangshan,Hebei 063000,China,2.Department of Neurosurgery,the People's Hospital of Tangshan City,3.Interventional Center,Xuanwu Hospital Affiliated to the Capital Medical University,Beijing 100053,China)) |
| Abstract: | Objective To investigate the mechanism of ligustrazine against cerebral ischemic/reperfusion injury in rats.Methods 25 Wistar male rats were chosen and randomly divided into normal control group(n=5),cerebral ischemic/reperfusion injury group(n=6),nimotop group(n=7)and ligustrazine group(n=7).Except normal control group,the other 3 groups were established as cerebral ischemic/reperfusion models by the way of improved Zea Longa method.The groups received injection of 0.9% sodium chloride,nimotop,and ligustra... |
| Keywords: | Ligustrazine Cerebral ischemia Reperfusion injury SOD Rat |
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