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Heterophile Hanganutziu-Deicher antigen in ganglioside fractions of human melanoma tissues
Authors:S Kawachi  T Saida  H Uhara  K Uemura  T Taketomi  K Kano
Affiliation:Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
Abstract:
Gangliosides were purified from melanoma tissue extracts obtained from 5 patients. GM3 and GD3 were identified as the major components in ganglioside fractions of the melanoma tissues. Following thin-layer chromatography, enzyme immunostaining with Hanganutziu-Deicher (H-D) antigen-specific chicken antisera demonstrated the presence of NeuGc-neolactotetraosylceramide (H-D5) and NeuGc-lacto-N-norhexa-osylceramide (H-D7) in all 5 melanoma extracts.
Keywords:
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