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不同e抗原状态的慢性乙肝及相关肝病的临床特点研究
引用本文:江宗群,李锐锋,陈世厚,段军. 不同e抗原状态的慢性乙肝及相关肝病的临床特点研究[J]. 临床军医杂志, 2014, 0(7): 685-687
作者姓名:江宗群  李锐锋  陈世厚  段军
作者单位:解放军第477医院感染科,湖北襄阳441003
摘    要:
目的探讨不同e抗原状态即HBeAg(-)和HBeAg(+)两类慢性乙型病毒性肝炎(CHB)及相关肝病的临床特点。方法对505例初次住院的CHB患者进行回顾性调查,分析HBeAg(-)和HBeAg(+)乙肝患者的性别、年龄、肝硬化及肝癌检出率、HBV DNA定量、肝组织病理学的组间差异。结果 HBeAg(-)组CHB患者年龄明显大于HBeAg(+)组,其肝硬化、肝癌发生率高,肝组织纤维化程度较HBeAg(+)组重;HBeAg(+)组CHB患者HBV DNA载量总体上高于HBeAg(-)组。结论 HBeAg(-)组CHB患者的预后差,临床工作者要重视HBeAg(-)组CHB患者的治疗。

关 键 词:慢性乙型肝炎  肝硬化  肝肿瘤  乙型肝炎病毒脱氧核糖核酸  组织学  乙型肝炎e抗原

Research on clinical characteristics of chronic hepatitis B and related liver diseases with different HBeAg status
Jiang Zongqun,Li Ruifeng,Chen Shihou,Duan Jun. Research on clinical characteristics of chronic hepatitis B and related liver diseases with different HBeAg status[J]. Clinical Journal of Medical Officer, 2014, 0(7): 685-687
Authors:Jiang Zongqun  Li Ruifeng  Chen Shihou  Duan Jun
Affiliation:(Department of Infectious Diseases, PLA 477th Hospital, Xiangyang Hubei 441003, China)
Abstract:
Objective To investigate the clinical characteristics of two different kinds ( i. e. HBeAg-negative or HBeAg-positive) of chronic hepatitis B (CHB) and related liver diseases. Methods A total of 505 patients with CHB treated in our department for the first time were retrospectively investigated. They were divided into two groups: HBeAg-negative group and HBeAg-positive group. Age, sex, detected rates of liver cirrhosis and cancer, HBV DNA and liver histological change were analyzed. Results The patients were significantly older in the HBeAg-negative group than in the HBeAg-positive group. Compared with those in the HBeAg- positive group, the patients in the HBeAg-negative group had higher incidences of liver cirrhosis and cancer, and more advanced hepatic fibrosis. The HBV DNA load of the HBeAg-positive group was higher than that of the HBeAg-negative group. Conclusion The prognosis of the CI-IB patients with negative HbeAg is worse than that of those with positive HBeAg. So they should be paid more attention to in clinical practice.
Keywords:chronic hepatitis B  hepatocirrhosis  hepatic neoplasm  hepatitis B virus DNA  histology  hepatitis B e antigen
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