三联疗法治疗不稳定心绞痛的临床应用

目的探讨三联疗法治疗不稳定心绞痛的临床价值。方法将确诊为不稳定心绞痛（UA）的150例患者随机分为三联组、二联组和对照组，每组各50例。三联组用硝酸甘油（NTG）10mg，肝素钠2500～10000U加入5％葡萄糖溶液500ml内，静脉点滴1～2次／d；罂粟碱30mg，肌肉注射，1—2次／d；7d为一疗程，停药1～2d后进行下一个疗程。二联组用NTG＋肝素钠，给药方法同三联组。对照组用50％葡萄糖溶液500ml加正大丹参20ml，静脉点滴，1～2次／d，7d为一疗程，停药1～2d后进行下一个疗程。结果三联组1d内心绞痛缓解率、心电图7d恢复率、总有效率均显著优于二联组和对照组（P均〈0．01）。结论三联疗法疗效显著，未见任何毒副反应，方法简便、经济实用，适用于基层医院，值得推广应用。

Clinical application of triple therapy in the treatment of unstable anaign pectoris

Objective To study the clinical valve of triple therapy in the treatment of unstable angina peetoris. Methods One hundred and fifty patients with unstable angina pectoris were randomly divided into the triple therapy group, the bigemina therapy group and the control group with 50 patients in each group. The triple therapy group was given nitroglycerin（NTG） 10 mg and heparin sodium 2 500 - 10 000 U in 500 ml 5% glucose injection by intravenous drip infusion once or twice daily;papaverine 30 mg by muscle injection once or twice daily. Seven days were used as a treatment course. The second treatment course was started after drug withdrawal of 1 - 2days. The bigeminy therap group was given NTG and heparin sodium whose administration methods were the same as those of the triple therapy group. The control group was given salvia injection （Chiatai Qingchtmbao Pharmacentical Co. Ltd） 20 ml in 500 ml 5% glucose injection by intravenous drip infusion once or twice daily. Seven days were used as a treatment course. The second treatment course was started after drug withdrawal of 1 - 2 days. Results The remission rate of angina pectoris within a doy, the recovery rate of electrocardiogram within 7 days and the total effective rate in the triple therapy group were significantly better than those in the bigeminy therapy group and the control group （ all P 〈 0. 01 ）. Conclusion The triple therapy has advantages of significant curative effect, no side effects, convenient operation, economy and practicality. It is suitable for basic hospital and worth using widely.