PGE_1与多巴胺联合应用治疗心肌梗塞后心源性休克(附两例报告)

<正> 当代治疗心力衰竭(以下简称心衰)的一个重要研究课题是探索最适宜的血管扩张剂与β-受体兴奋剂联合应用,以克服其不利作用,而使有益效应发挥到最大限度。自从70年代初期血管扩张剂应用于心衰治疗以来,血管扩张剂与β-受体兴奋剂联合应用,国外进行了许多研究,国内也有应用酚妥拉明和多巴胺静点治疗急性心衰伴血压明显降低甚至休克的病人,取得了满意疗效。有人预计今后将发现更有效的药物,其中,对血管平滑肌有特异作用的前列腺素(PGE),可能是有前途的血管扩张剂。作者于1981年12月应用白求恩医科大学药物研究室制前列腺素E_1(PGE_1)与多巴胺联合应用对两例心肌梗塞合并心衰伴低血压休克得到了满意的治疗效果,报告如下:

Application of PGE_1 with Dopamine to Treatment of Cardiac Shock following Cardiac Infarction

PGE1 is believed to be probably the most promising vasodilator administered in conjunction with an activator of beta-receptors to exert beneficial effects on cardiac shock following cardiac infarction. In 1981 we applied PGE1 with dopamine to treatment of 2 patients with cardiac shock complicating acute myocardial infarction. The 2 patients were women aged 62 and 84 years respectively, having similar symptoms and signs. PGE1 in combination with dopamine was infused intravenously with satisfactory results in both cases.(P70)