| 胃泌素及其受体与胃癌关系的研究进展 |
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| 引用本文： | 王春云,郑侃侃,谢文彪. 胃泌素及其受体与胃癌关系的研究进展[J]. 国际外科学杂志, 2014, 41(7): 490-494 |
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| 作者姓名： | 王春云 郑侃侃 谢文彪 |
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| 作者单位： | 王春云 (南华大学附属第二医院胃肠外科, 衡阳,421001)； 郑侃侃 (南华大学附属第二医院胃肠外科, 衡阳,421001)； 谢文彪 (南华大学附属第二医院胃肠外科, 衡阳,421001)； |
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| 摘 要： | 胃泌素主要由胃窦及小肠上段黏膜的G细胞分泌,其受体分布在多种器官组织中.胃泌素及其受体具有调节细胞生长、分化,抑制细胞凋亡,促进细胞增生、侵袭、转移的功能.研究表明,胃泌素及其受体参与包括胃癌在内的多种肿瘤的发生、发展.胃泌素及其受体还可作为胃癌早期诊断的一个重要指标,同时也可能是胃癌治疗的潜在靶点.本文就胃泌素及其受体与胃癌的发生、发展关系作一综述.
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| 关 键 词： | 胃泌素 胃泌素受体 胃肿瘤 |
Gastrin and its receptor with gastric carcinoma |
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| Wang Chunyun,Zheng Kankan,Xie Wenbiao. Gastrin and its receptor with gastric carcinoma[J]. International Journal of Surgery, 2014, 41(7): 490-494 |
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| Authors: | Wang Chunyun Zheng Kankan Xie Wenbiao |
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| Affiliation: | (Department of Gastrointestinal Surgery, Second Affiliated Hospital of Nanhua University, Hengyang 421001, China) |
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| Abstract: | Gastrin is mainly secreted by the G cells in antrum and the upper part of small intestine.Gastrin receptor distributes in various tissues.Gastrin and its receptor have several functions including regulating cell growth and differentiation,inhibiting apoptosis,promoting cell proliferation,invasion and metastasis.Studies have shown that gastrin and its receptor involve with various cancers occurrence and development.Gastrin and its receptor can be used to diagnosis early gastric cancer,and be used as a potential targets in gastric carcinoma treatment.The relationship of gastrin and its receptor with gastric carcinoma were reviewed in this paper. |
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| Keywords: | Gastrin Gastrin receptor Stomach neoplasmas |
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