高血压病患者内皮素、一氧化氮测定的临床意义

目的：了解内皮素、一氧化氮在高血压发病中的作用。方法：放射免疫分析法检测94例高血压病患者血浆中内皮素（ET）含量,并与35名正常人作对照。同时采用Greiss法检定亚硝酸盐及硝酸盐以间接测定一氧化氮（NO）含量。结果：高血压病患者血ET水平显著地高于正常人（P＜0.01),而NO水平则明显下降（P＜0.01),且与病情的程度有一定的关系。结论：测定高血压病血ET和NO水平的变化与高血压的发生和发展密切相关。

The Significance of detecting the ET and NO levels in Hypertension patients

Objective: In order to study the role of plasma ET and NO in the cause of Hypertension patients. Methods: The Concentrations of plasma ET was detected by radioimmunoassay in 94 patients with Hypertension and 35 normal controls. Meantime plasma NO 2 - / NO 3 - levels, the stable metabolic end product of NO was determined with Greiss determination. Results: The plasma ET levels in patients with Hypertension were significantly higher than those in normal control (P<0.01).While plasma NO levels were decreased markly(P<0.01). The score index of Hypertension had significant correlation with the levels of plasma ET?NO. Conclusion: It was shows that the ET NO are concened with the Occurrence and development of the Hypertension patients.