中医药干预老年晚期非小细胞肺癌患者的生存研究

目的:探讨接受中医药干预的老年晚期非小细胞肺癌患者的生存状况及其预后的影响因素.方法:回顾性分析103例接受中医药干预持续3个月及以上的老年(年龄≥65岁)晚期(ⅢB或Ⅳ期)非小细胞肺癌患者的临床资料,利用SPSS 16.0统计软件COX回归模型分析年龄、性别、病理、临床分期、合并症、治疗方法、中医药干预持续时间等预后...

Survival Analysis of Elderly Patients with Advanced Non-small CellLung Cancer Received Traditional Chinese Medicine Intervention

Objective： To analyze the survival time and prognostic factors of the elderly patients with advanced non-small Cell lung cancer（NSCLC） received traditional Chinese medicine（TCM） intervention.Methods： One hundred and three elderly patients（≥65 years） with advanced（stage ⅢB or Ⅳ） NSCLC received TCM intervention more than three months were retrospectively analyzed.The potential prognostic factors,including age,sex,pathological types,clinical stage,comorbidity,treatment strategies and TCM intervention duration were analyzed by COX regression with SPSS 16.0 software.Results： The median survival time（MST） of 103 elderly patients with advanced NSCLC was 16.12 months and their 1,3,5-year survival rates were 60%,16% and 3% respectively.The univariate analysis showed that the significant prognostic factors were the sex（P=0.035）,clinical stage（P=0.029）,comorbidity（P=0.000）,treatment strategies（P=0.018）,and TCM intervention duration（P=0.000）,and the COX regression multivariate analysis suggested that the comorbidity（P=0.000）,treatment strategies（P=0.005） and TCM intervention duration（P=0.000） were the independent prognostic factors respectively.Conclusion： Comorbidity is the independent prognostic factor of increasing the death risk of elderly patients with advanced NSCLC,and the TCM intervention of long time and the integrated Chinese and western medicine treatment can prolong the survival time.