| 曲妥珠单抗联合辅助化疗治疗晚期乳腺癌的临床观察 |
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| 引用本文： | 孙宏治,王巍,李晴,李强,杨涛,李东升. 曲妥珠单抗联合辅助化疗治疗晚期乳腺癌的临床观察[J]. 中国生化药物杂志, 2011, 32(5) |
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| 作者姓名： | 孙宏治 王巍 李晴 李强 杨涛 李东升 |
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| 作者单位： | 1. 辽宁医学院附属第一医院,普外科,辽宁,锦州,121001
2. 辽宁医学院附属第三医院肾内科,辽宁,锦州,121001 |
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| 基金项目： | 辽宁省锦州市科技局科学技术计划项目(10A1E37) |
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| 摘 要： | 目的观察曲妥珠单抗联合辅助化疗治疗晚期乳腺癌的临床疗效及不良反应。方法选择120例改良根治术的乳腺癌患者,病理诊断均为晚期癌,随机分两组:60例接受常规化疗患者为对照组,60例接受曲妥珠单抗联合辅助化疗治疗的患者为实验组。比较两组的生存率、复发率、转移率和不良反应。结果对照组局部复发率为13.3%,远处转移率11.7%,其中1例死亡。实验组局部复发率为1.7%,无远处转移,全部生存。两组复发率、转移率之间的差异均有统计学意义(P<0.05),而生存率无明显差异(P>0.05)。两组不良反应发生率无明显差异。结论曲妥珠单抗联合辅助化疗是目前治疗晚期乳腺癌患者的一种安全有效的方法,能明显减少乳腺癌术后的复发率和转移率。
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| 关 键 词： | 曲妥珠单抗 乳腺癌 化疗 |
Clinical observation of trastuzumab plus adjuvant chemotherapy for advanced breast cancer |
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| SUN Hong-zhi,WANG Wei,LI Qing,LI Qiang,YANG Tao,LI Dong-sheng. Clinical observation of trastuzumab plus adjuvant chemotherapy for advanced breast cancer[J]. Chinese Journal of Biochemical Pharmaceutics, 2011, 32(5) |
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| Authors: | SUN Hong-zhi WANG Wei LI Qing LI Qiang YANG Tao LI Dong-sheng |
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| Affiliation: | SUN Hong-zhi1,WANG Wei1,LI Qing2,LI Qiang1,YANG Tao1,LI Dong-sheng1(1.Department of General Surgery,the No.1 Affiliaed Hospital,2.Department of Renal Medicine,the No.3 Affiliaed Hospital,Liaoning Medical University,Jinzhou 121001,China) |
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| Abstract: | Purpose To study the efficacy and adverse reactions of trastuzumab plus adjuvant chemotherapy for advanced breast cancer.Methods 120 cases of modified radical mastectomy for breast cancer patients,with advanced carcinoma diagnosed pathelogically,randomly divided into two groups,60 patients received conventional chemotherapy for the control group,60 patients received trastuzumab combined adjuvant chemotherapy treatment experimental group patients were compared in survival,recurrence rate,metastasis rate and ... |
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| Keywords: | trastuzumab breast cancer chemotherapy |
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