重症胰腺炎血浆内毒素水平变化及临床意义

探讨血浆内毒素（ｅｎｄｏｔｏｘｉｎ，ＥＴ），在急性胰腺炎（ａｃｕｔｅ ｐａｎｃｒｅａｔｉｔｉｓ，ＡＰ）发生、发展中的作用。根据Ｒａｎｓｏｎ系列预后判断标准，影像学和病理学检查（手术病例）将３２例患者分为４组，每组８例。Ａ组：轻型ＡＰ；Ｂ组重症ＡＰ非手术治疗；Ｃ组：重着ＡＰ手术治疗；对照组：不伴急性炎症的胆囊结石病 列。分别于入院时或术前、治疗后或术后第１、２、３、６及１０天采血作ＥＴ测定。另外收集

CHANGES AND CLINICAL SIGNIFICANCE OF PLASMA ENDOTOXIN LEVEL IN ACUTE SEVERE PANCREATITIS

The purpose of this study was to determine the contribution of endotoxin (ET) in ocurrence and progression of acute pancreatitis (AP). The results indicated that correlation of ET changes with multiple organ damage in AP. The degree of ET elevation correlated well with the severty of AP. The level of plasma ET of severe AP patients was much higher than that of mild AP patients ( P <0.05). The chance of multiple organ damage got greater while the plasma ET level got higher. Moreover, the severety change of severe AP correlated with the change of plasma ET level. In other words, the ET level was reduced while the disease was recovering, elevated while it was becoming worse and maintained high level in dead cases. We think that plasma ET level can be used as a reference for differenciating mild AP with severe AP and a predictor for the prognosis of AP.