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| 复方丹参滴丸及其主要成分丹参、三七对缺血再灌注引起的大鼠肠系膜微循环障碍的多环节改善作用 | |
| 引用本文： | 韩晶岩,秋叶保忠,堀江义则,永田博司,石井裕正,日比纪文,三浦总一郎. 复方丹参滴丸及其主要成分丹参、三七对缺血再灌注引起的大鼠肠系膜微循环障碍的多环节改善作用[J]. 世界科学技术-中医药现代化, 2008, 10(3): 99-105 |
| 作者姓名： | 韩晶岩 秋叶保忠 堀江义则 永田博司 石井裕正 日比纪文 三浦总一郎 |
| 作者单位： | 北京大学医学部天士力微循环研究中心,北京,100083;北京大学基础医学院中西医结合教研室,北京,100083;日本庆应义塾大学医学部消化内科,日本,东京,160-8582;日本庆应义塾大学医学部消化内科,日本,东京,160-8582;日本防卫医科大学内科,日本,琦玉,359-8513 |
| 基金项目： | 国家科技部中医药国际合作专项(2006DFA32340):复方丹参滴丸的国际合作研究 |
| 摘 要： | 目的:本研究探讨复方丹参滴丸(cardiotonic pill@,CP)及其主要成分丹参、三七对(is-chemia/repezfusion,I/R)引起的大鼠肠系膜微循环障碍的改善作用.方法:用连接于彩色摄影机、高敏感摄影机的倒置生物显微镜观察和纪录Wistar雄性大鼠肠系膜微循环的动态.将肠系膜动静脉同时结扎10min,然后解除结扎,建立I/R模型.假手术组(Sham)不做I/R处理.I/R处理60分前,Sham和I/R组灌胃给予生理盐水.CP I/R组、丹参 I/R组、三七 I/R组分别灌胃给予CP、丹参水提物和三七水提物(各0.4g/Kg).结果:丹参水提物可以抑制白细胞的粘附,抑制细静脉血管壁过氧化物,抑制FITC标记白蛋白的漏出.三七水提物可以抑制白细胞的粘附、肥大细胞脱颗粒.CP可以抑制白细胞的粘附、细静脉血管壁过氧化物、肥大细胞脱颗粒和FITC标记白蛋白的漏出.结论:CP多环节改善作用缺血再灌注引起的微循环障碍的作用是其所含有的丹参水提物和三七水提物相须作用的结果. |
| 关 键 词： | 复方丹参滴丸 缺血再灌注 过氧化物 细胞黏附 肥大细胞 白蛋白漏出 |
| 收稿时间： | 2008-05-06 |
| 修稿时间： | 2008-06-01 |
Attenuating Effects of Cardiotonic Pill@ and Its Major Ingredients,Salviae Miltiorrhiza,and Panax Notoginseng on the Microcirculatory Disturbance Induced by Ischemia and Reperfusion in Rat Mesentery. |
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| Han Jingyan,Yasutada Akib,Yoshinori Horie,Hiroshi Nagat,Soichiro Miur,Hiromasa Ishii and Toshifumi Hibi. Attenuating Effects of Cardiotonic Pill@ and Its Major Ingredients,Salviae Miltiorrhiza,and Panax Notoginseng on the Microcirculatory Disturbance Induced by Ischemia and Reperfusion in Rat Mesentery.[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2008, 10(3): 99-105 | |
| Authors: | Han Jingyan Yasutada Akib Yoshinori Horie Hiroshi Nagat Soichiro Miur Hiromasa Ishii Toshifumi Hibi |
| Affiliation: | Tasly Microcirculation Research Center; Beijing University Health Science Center; 100083 Beijing; China; Department of Integration of Chinese and Western Medicine; Department of Internal Medicine; School of Medicine; Keio University; 160-8582; Tokyo; Japan;Department of Internal Medicine; Japan;Department of Internal Medicine; Japan;Department of Internal Medicine; Japan;Department of Internal Medicine; Japan;Department of Internal Medicine; Japan;Department of Internal Medicine; Japan |
| Abstract: | This is a study to understand the effects of cardiotonic pill@ (CP) and its major ingredients,Salviae Miltiorrhiza (SM),and Panax Notoginseng (PN),on the microcirculatory disturbance induced by ischemia and reperfusion (I/R) in rat mesentery.In the study,researchers had a dynamic examination of microcirculation of mesentery of Wistar rats us- ing an invert microscope equipped with a 3 charge-coupled device camera and a silicon-intensified target camera.I/R injuries were induced by ligation of the mesenteric... |
| Keywords: | cardiotonic pill@ ischemia and reperfusion peroxides cell adhesion mast cell albumin efflux |
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