藏药烈洗的减肥和促进LDLR表达的作用研究

目的:探讨藏药烈洗对高脂饮食诱导的肥胖大鼠的治疗作用以及烈洗所含化学成分对低密度脂蛋白受体（LDLR）的影响。方法:采用高脂饮食喂养诱导建立大鼠肥胖模型,检测药物对肥胖大鼠体重、体脂重、脂／体比的影响;建立低密度脂蛋白受体荧光素酶报告基因系统,检测烈洗所含化学成分对荧光素酶活性的影响。结果:烈洗提取物能够明显减轻高脂饮食诱导的肥胖大鼠的体重及体脂重,使脂／体比降低;其所含部分化学成分使荧光素酶活性增强。结论:烈洗对高脂饮食诱导的肥胖具有明显的治疗作用,其所含化学成分具有促进低密度脂蛋白受体表达的作用。

Effects of Eugenia Caryophyllata Thunb. on Reduction of Obesity and Stimulation of LDLR Expression

Objective To discuss the curative effect of Eugenia caryphyllata Thunb., a traditional medicine of Zang nationality in China, on fat rats forced by high-fat diet and the effect of its chemical components on LDLR. Method To select high-fat diet for rats in order to establish a model of fat rats and then inspect the impact of the said medicine on the weight, the weight of body fat and body/ weight ratio of the fat rats, and to establish a gene system of LDLR luciferase report in order to inspect the impact of chemical components of Eugenia carypophyllata Thunb. on the activity of luciferase. Result The extracts of Eugenia caryphyllat Thunb. can apparently be able to reduce the weight and the weight of body fat of fat rats fed by high-fat diet and lower down their body/weight ratio, and part of the chemical components of this medicine can enhance the activity of luciferase. Conclusion Eugenia caryophyllata Thunb. has obvious effect of reducing fat resulting from high-fat diet and its chemical components are endowed with the role of stimulating the expression of LDLR.