| 甘遂对胃肠平滑肌的作用特点及其用于质量控制指标的可行性 |
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| 引用本文： | 王秀坤,肖新月,花 雷,程显隆,王玉刚,邢东明,胡 珺,雷 帆,杜力军.甘遂对胃肠平滑肌的作用特点及其用于质量控制指标的可行性[J].世界科学技术-中医药现代化,2009,11(5):707-711. |
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| 作者姓名： | 王秀坤 肖新月 花 雷 程显隆 王玉刚 邢东明 胡 珺 雷 帆 杜力军 |
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| 作者单位： | 清华大学生物科学与技术系药物药理研究室 北京 100084;中国药品生物制品检定所中药研究室 北京 100050;清华大学生物科学与技术系药物药理研究室 北京 100084;中国药品生物制品检定所中药研究室 北京 100050;清华大学生物科学与技术系药物药理研究室 北京 100084;清华大学生物科学与技术系药物药理研究室 北京 100084;清华大学生物科学与技术系药物药理研究室 北京 100084;清华大学生物科学与技术系药物药理研究室 北京 100084;清华大学生物科学与技术系药物药理研究室 北京 100084 |
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| 基金项目： | 科技部国家“十一五”科技支撑项目（2006BAI14B01）：常见与重要药品安全标准研究，子课题负责人：肖新月；科技部国家“十一五”科技支撑计划项目（2006BAI08B03-09）：中药复方质量控制与评价方法研究-吴茱萸汤，药效负责人：杜力军；中国博士后科学基金（20080440418）：吴茱萸汤与吴茱萸对血管及胃肠平滑肌作用的比较研究，负责人:王秀坤。 |
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| 摘 要： | 目的：观察甘遂醇提取物对胃肠平滑肌作用的活性及其特点，探讨其作为全方质量控制方法的可行性。方法：利用体内体外实验对胃、小肠平滑肌收缩活性进行观察。结果：甘遂醇提取物对小肠和胃平滑肌收缩具有明显的抑制作用，同时明显降低其张力，体内给药可能明显刺激小鼠排稀便，且重现性较好。结论：甘遂的这种对胃肠平滑肌、以及排稀便的作用可以作为对该药品质综合评定的指标。
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| 关 键 词： | 甘遂 胃肠平滑肌 药效 质量控制 |
| 收稿时间： | 2009/6/17 0:00:00 |
| 修稿时间： | 2009/8/11 0:00:00 |
Euphorbia Kansui Effect on Gastro-intestinal Smooth Muscle and Possibility for its Quality Control Based on its Clinical Application |
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| Wang Xiukun,Xiao Xinyue,Hua Lei,Cheng Xianlong,Wang Yugang,Xing Dongming,Hu Jun,Lei Fan and Du Lijun.Euphorbia Kansui Effect on Gastro-intestinal Smooth Muscle and Possibility for its Quality Control Based on its Clinical Application[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2009,11(5):707-711. |
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| Authors: | Wang Xiukun Xiao Xinyue Hua Lei Cheng Xianlong Wang Yugang Xing Dongming Hu Jun Lei Fan and Du Lijun |
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| Institution: | Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China;Laboratory of Chinese Materia Medica, National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China;Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China;Laboratory of Chinese Materia Medica, National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China;Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China;Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China;Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China;Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China;Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China |
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| Abstract: | This study aimed to observe the activity and the characteristic of ethanol extracts from Euphorbia kansui on gastro-intestinal smooth muscle, and to investigate the feasibility of using E. Kansui as one criterion for the medicine quality control. The contraction of the stomach and small intestine was tested in vitro. The results showed that the ethanol extract from Euphorbia kansui significantly inhibited the contraction of gastro-intestinal smooth muscle and reduced its tension. In vivo administration might greatly stimulate the excretion of liquid manure, with good reapeatability. E. kansui has some effect on gastro-intestinal smooth muscle and excretion of liquid manure, making it a candidate criterion for the medicine quality control. |
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| Keywords: | Euphorbia kansui Gastro-intestinal smooth muscle Pharmacologic effect Quality control |
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