| 低分子壳聚糖季铵盐对小鼠实体瘤及其免疫系统的影响 |
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| 引用本文： | 张建国,任慧霞,刘其凤,韦玉军. 低分子壳聚糖季铵盐对小鼠实体瘤及其免疫系统的影响[J]. 中国生化药物杂志, 2005, 26(2): 93-95 |
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| 作者姓名： | 张建国 任慧霞 刘其凤 韦玉军 |
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| 作者单位： | 山东大学,药学院,生化与生物技术药物研究所,山东,济南,250012 |
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| 摘 要： | 目的研究低分子壳聚糖季铵盐对小鼠S180 和机体免疫功能的影响。方法采用抑瘤实验、碳粒廓清实验、MTT法观察低分子壳聚糖季铵盐对小鼠实体瘤和免疫系统的影响。结果低分子壳聚糖季铵盐可使荷瘤小鼠的碳粒廓清指数、胸腺指数、脾脏指数升高,并对由ConA、脂多糖诱导体外小鼠T ,B淋巴细胞增殖有明显的兴奋作用;能够抑制小鼠实体瘤的生长。结论低分子壳聚糖季铵盐能够增强机体的免疫功能,并具有抑瘤作用
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| 关 键 词： | 低分子壳聚糖季铵盐 免疫功能 抑瘤 |
| 文章编号： | 1005-1678(2005)02-0093-03 |
| 修稿时间： | 2004-10-12 |
Effects of low molecular N-trimethyl chitosan chloride on solid tumor and immune system in mice |
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| ZHANG Jian-guo,REN Hui-xia,LIU Qi-feng,WEI Yu-jun. Effects of low molecular N-trimethyl chitosan chloride on solid tumor and immune system in mice[J]. Chinese Journal of Biochemical Pharmaceutics, 2005, 26(2): 93-95 |
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| Authors: | ZHANG Jian-guo REN Hui-xia LIU Qi-feng WEI Yu-jun |
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| Abstract: | PurposeTo study the effects of low molecular N-trimethyl chitosan chloride on solid tumor and immune system in mice.MethodsUsing inhibiting tumor experiment,carbon clearance test and MTT method to observe the influences of low molecular N-trimethyl chitosan chloride on the solid tumor and immune system in mice.ResultsLow molecular N-trimethyl chitosan chloride could increase the carbon clearance,thymus and spleen index in tumor-bearing mice. And it could apparently enhance lymphocyte proliferations of T and B induced by ConA and LPS. It had the activity of suppressing the growth of solid tumor in mice.ConclusionLow molecular N-trimethyl chitosan chloride could enhance the immune function and had anti-cancer activity. |
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| Keywords: | low molecular N-trimethyl chitosan chloride immune function antitumor |
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