卵巢低反应患者中医症候分布研究

目的：研究171例卵巢低反应患者的中医证候分布规律。方法：对171例患者进行信息采集,采用变量聚类分析研究卵巢低反应患者的证型分布特点,探讨其证候分布规律及规范化证型。同时比较不同中医证型患者年龄、注射绒毛膜促性腺激素（HCG）当日血清雌二醇（E2）水平、获卵数和周期取消情况。结果：卵巢低反应患者主要表现为肝郁肾虚、肾气阴两虚、脾肾阳虚3种证型。其中肝郁肾虚证患者最多,共75例占43.86%,其次是肾气阴两虚证患者,共64例占37.43%,脾肾阳虚证患者共19例占11.11%,其他证型13例占7.61%。肾气阴两虚组患者年龄高于其他组,差异有统计学意义（P〈0.05）,肾气阴两虚组患者获卵数、HCG日E2水平均低于肝郁肾虚组,差异有统计学意义（P〈0.05）。肾气阴两虚组患者周期取消率高于其他组（P〈0.05）。结论：卵巢低反应患者临床所出现中医证型按出现频率由高到低为肝郁肾虚、肾气阴两虚、脾肾阳虚、其它证型。肾气阴两虚证患者年龄、周期取消率可能高于其他证型患者,肾气阴两虚证患者HCG日E2水平和获卵数可能低于其他证型患者。

Chinese Medical Syndrome Disposition of Poor Ovarian Responders

Objective： To study Chinese medical syndrome disposition of 171 cases of patients with poor ovarian response （ POR ）. Methods ： The information acquisition and cluster analysis were used to research Chinese medical syndrome disposition in 171 cases of patients with POR. The level of estradiol （E2 ）at the date of human chorionic gonadotrophin （ HCG ） injection and the number of oocytes were compared among different syndromes. Results ： The major syndromes were liver depression and kidney syndrome （ 75 case,43.86% ）, both deficiency of kidney qi and yin syndrome （64 caes,37.43% ）and spleen-kidney yang deficiency syndrome （ 19 cases, 11.11%）. The rest 13 cases of other syndromes accounted for 7.61%. The age of both deficiency of kidney qi and yin syndrom was significantly higher than those of other syndromes （ P〈0.05 ）. The number of oocytes and E2 level of both deficiency of kidney qi and yin syndrom was significantly lower than that of the liver depression and kidney syndrome （ P〈0.05 ）. The differences between other syndromes were not stastistically significant （P〈0.05 ）. The cycle cancellation rate of both deficiency of kidney qi and yin syndrom was higher than those of other syndromes （ P〈0.05 ）. Conclusion ： The syndrome frequency of POR from high to low is liver depression and kidney syndrome, both deficiencyof kidney qi and yin syndrome, spleen-kidney yang deficiency Syndrome and other syndromes. The ages and the cycle cancellation rate of both deficiency of kidney qi and yin syndrome may be higher than that of other syndromes and the number of oocytes and E2 level of both deficiency of kidney qi and yin syndrome may be lower than that of other syndromes.