E-cadherin的表达与食管鳞癌发生、发展的免疫组化研究

目的 :检测E cadherin(E cad)在食管粘膜上皮癌变发生各个阶段的表达 ,探讨其在食管鳞癌发生、发展中的作用以及和预后的关系。方法 :应用免疫组化SP法检测 ,食管粘膜上皮癌变发生各阶段 ( 19例食管正常上皮→2 3例单纯性增生→ 2 1例轻度不典型增生→ 17例重度不典型增生→ 5 2例鳞癌 )中E cad的表达。结果 :随着病变的发展 ,E cad的阳性表达率逐渐降低 ,其中重度不典型增生组与鳞癌组分别与食管正常上皮组和单纯性增生组比较 ,均有非常显著性差异 (P <0 0 1) ,E cad的表达减少与食管鳞癌的组织学分级 ,浸润深度和淋巴结转移相关。结论 :E cad是一个潜在的肿瘤抑制基因 ,E cad正常表达对食管鳞癌的浸润转移有一定抑制作用

Immunohistichemical study on E-c adherin expression and relation to carci nogenesis and development of esophageal squamous cell carcinoma

Objective: To investigate the role of E cadherin(E cad) in the carcinogenesis and development of esophageal squamous cell carcinoma(ESCC).Methods: Immunohistochemical method was used to examine E cad expression in each stage of the carcinogenesis and development of ESCC (normal esophageal epithelial→23 simple hyperplasia→21 mild atypical hyperplasia→17 severe atypical hyperplasia→52 ESCC).Results: The positive expression rate of E cad decreased gradually with the progression of the esophageal mucosa lesions.There were very significent differences ( P <0.01) when the severe atypical hyperplasia group and the ESCC group were compared with the normal esophageal epithelial group and the simple hyperplasia group respectively.There were distinct correlations between the decreased expression rate of E cad and the histological grades,depth of infiltration and lymph node metastasis ( P <0.05).Conclusion: E cad is a potential tumor suppress gene,the normal expression of E cad can inhibit the infiltration and the metastasis of ESCC.