| 白色念珠菌的耐药性和随机扩增DNA多态性分型研究 |
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| 引用本文： | 钱骏,查国章,余平. 白色念珠菌的耐药性和随机扩增DNA多态性分型研究[J]. 中南大学学报(医学版), 2000, 25(4): 327-330 |
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| 作者姓名： | 钱骏 查国章 余平 |
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| 作者单位： | |
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| 摘 要： | 采用Etest药敏试验方法检测 30株临床分离白色念珠菌对 5种抗真菌药物的敏感性 ,并用随机扩增DNA多态性 (RAPD)分型方法对这些菌株进行基因分型。结果发现有两株对氟康唑耐药 ,且它们的RAPD带型有着高度相似性 ,提示RAPD带型可能与耐氟康唑基因有关。
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| 关 键 词： | 白色念珠菌 多态性 基因型 Etest药敏试验 抗真菌剂 药物抗药性,微生物 , |
| 修稿时间： | 1999-06-30 |
Candida albicans resistance and genotyping by randomly amplified polymorphic DNA method |
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| QIAN Jun,ZHA Guo zhang,YU Ping. Candida albicans resistance and genotyping by randomly amplified polymorphic DNA method[J]. Journal of Central South University. Medical sciences, 2000, 25(4): 327-330 |
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| Authors: | QIAN Jun ZHA Guo zhang YU Ping |
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| Affiliation: | Department of Immunology, Hunan Medical University(Changsha 410078) |
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| Abstract: | The Etest was used to determine the minimum inhibitory concentrations(MICs) of five antifungal agents for 30 C. albicans clinical isolates. Randomly amplified polymorphic DNA(RAPD) analysis was established and was used to type 30 epidemiological unrelated strains of C. albicans. The relationship between genotype of C. albicans and its resistance to antifungal was analysed by dendrogram according to RAPD patterns. The results were that there were 2 of 30 isolates of C. albicans against fluconazole and their RAPD profiles had high similarity. These results suggest that a high degree of genetic correlation exists between fluconazole resistant patterns and RAPD profiles of C. albicans. |
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| Keywords: | C. albicans polymorphism genotype Etest * antifugal agents drug resistance microbial |
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