艾司西酞普兰联合渐进性肌肉放松训练治疗惊恐障碍的效果评价

目的探讨艾司西酞普兰联合渐进性肌肉放松训练对惊恐障碍的疗效。方法采用随机数字表法将80例符合《中国精神障碍分类与诊断标准(第3版)》(CCMD-3)惊恐障碍的诊断标准的患者分为研究组和对照组各40例,研究组予艾司西酞普兰联合渐进性肌肉放松训练治疗,对照组单用艾司西酞普兰治疗,观察12周。于治疗前、治疗2、4、8、12周末采用汉密顿焦虑量表(HAMA-14)进行评分;治疗前和12周后采用生活质量量表(SF-36)标准版对两组生活质量评估。结果治疗前两组HAMA和SF-36评分差异无统计学意义(P0.05),治疗4周后两组HAMA评分均较治疗前降低,差异有统计学意义(P0.01);治疗12周后,研究组SF-36总评分及各因子分优于对照组(P0.05)。结论艾司西酞普兰联合渐进性肌肉放松训练可以缓解惊恐障碍患者的焦虑情绪,并能改善患者治疗后的生活质量。

The effect evaluation of Escitalopram combined progressive muscle relaxation training in panic disorder

Objective To observe the curative effect of combination treatment with escitalopram and progressive muscle relaxa-tion training for panic disorder. Methods 80 cases,in which panic disorder were diagnosed with the Chinese classification of mental disorders and diagnosis standard （ third edition） （ CCMD-3 ） diagnostic criteria , were divided into research group and the control group （ n=40 ） by the random number table . Research group was treated both with aicitalopram and progressive muscle relaxation training ,While the control group was treated with escitalopram citalopram alone. All the patients were observed for 12 weeks. Hamilton anxiety scale （HAMA-14） was performed before treatment and 2, 4, 8, 12 weeks after the treatment, meanwhile, the quality of life in the two groups were evaluated by the standard version of quality of life scale （SF-36） . Results Before the treatment,the differ-ence of HAMA, SF - 36 score in two groups was not significant （P〉0. 05）. 4 weeks after the treatment, HAMA scores both in the two groups were reduced and the difference was statistically significant compared with that before the treatment（P〈0. 01）. Since 8 weeks after the treatment, HAMA scores in research group were decreased more significantly compared with the control group （ P〈0. 01）. 12 weeks after the treatment, the total scores of SF-36 and all factor scores are improved more better than that of control group （P〈0. 05）. Conclusion The combination treatment with escitalopram and progressive muscle relaxation training not only can alleviate the anxiety of the patients with panic disorder, but also can improve the quality of life of the patients.