度洛西汀治疗老年抑郁症对照研究的Meta分析

目的探讨度洛西汀治疗老年抑郁症的疗效和不良反应的差异。方法应用Meta分析对10篇度洛西汀治疗老年抑郁症对照研究的文章进行再分析,评价其合并效应量大小并进行显著性检验。结果 1度洛西汀自身对照比较的治疗效应极大,合并效应量d=4.59,95%CI(3.01,6.17),χ2=21.5,P0.01;2度洛西汀与氯氮平在第2周末和治疗后组间比较,疗效差异无统计学意义(P0.05),差异效应偏小,分别为Y合并=-0.04,95%CI(-0.19,0.11),χ2=3.86,P0.05;Y合并=0.01,95%CI(-0.14,0.17),χ2=3.06,P0.05;3两组不良反应差异无统计学意义(P0.05)。结论度洛西汀治疗老年抑郁症疗效好,不良反应少。

Meta-analysis of comparative study of duloxetine in the treatment of senile depression

Objective To study the difference of efficacy and side effect of duloxetine in the treatmrent of senile depression. Methods 10 comparative studies of duloxetine and other antidepressants in the treatment of senile depression were analyzed by meta-analysis. Results ①Self-comparison study of duloxetine before and after treatment showed that d=4. 59,95%CI（3. 01,6. 17）,χ^2=21. 5,P〈0. 01. Comparison between duloxetine and the controlled antidepressants at 2 weeks treatment and at the end of each tril showed that Yco = -0. 04,95%CI（ -0. 19,0. 11）,χ^2=3. 86,P〉0. 05, and Yco =0. 01,95%CI（ -0. 14,0. 17）,χ^2=3. 06,P〉0. 05 respectiveiy,which revealed that there was no significant difference between duloxetine and the controlled antidepressants with respect to the clinical efficacy. There were no significant difference in side effect between these two groups. Conclusion Duloxetine is an safe and effective antidepressant in the treatment of senile depression.