首页 | 本学科首页   官方微博 | 高级检索  
     


Soluble urokinase plasminogen activator receptor in type 1 diabetic children,relation to vascular complications
Authors:Eman Mounir Sherif  Abeer Ahmed Abd El Maksood  Omneya Ibrahim Youssef  Nouran Yousef Salah El-Din  Ola Khaled Mohamed Khater
Affiliation:Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract:
BackgroundEndothelial dysfunction caused by chronic inflammation is the cornerstone of vascular complications in type 1 Diabetes-Mellitus (T1DM). Soluble Urokinase Plasminogen Activator Receptor (SuPAR) is a novel marker of inflammation and endothelial dysfunction.AimTo evaluate SuPAR in T1DM children and correlate it to diabetic vascular complications.MethodsSeventy T1DM children and 40 matched healthy controls were studied focusing on disease duration, insulin therapy and symptoms of diabetic complications. Blood-pressure, fundus and screening for peripheral-neuropathy were done. Fasting lipid profile, fraction-C of glycosylated hemoglobin (HbA1c%), Urinary albumin excretion (UAE), estimated-glomerular filtration rate (eGFR) and SuPAR were measured. Internal aortic diameter was measured with calculation of aortic distensibility and stiffness index.ResultsSixteen T1DM patients(22.9%) had peripheral neuropathy, 12(17%) had nephropathy and none had retinopathy. SuPAR was significantly elevated in diabetic nephropathy (p < 0.01) and neuropathy (p < 0.01). Aortic stiffness index was significantly higher (p < 0.01) whereas, aortic strain and distensibility were significantly lower (p < 0.01) in T1DM than controls. SuPAR was significantly correlated to disease duration (p < 0.01), systolic blood pressure (p < 0.01), total cholesterol (p < 0.01), triglycerides (p < 0.01), UAER (p < 0.01) and aortic strain (0.013).ConclusionIncreased SuPAR early in diabetes might become a useful indicator of developing vascular complications. Further prospective studies are needed to determine the cut-off level of SuPAR for detection of T1DM and its complications.
Keywords:Corresponding author at: 25 korash street, Cairo, Egypt.  Soluble urokinase plasminogen activator  Type 1 diabetes  Nephropathy  Neuropathy  Retinopathy
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号