Prevalence of Restless Legs Syndrome and Its Effects on Sleep and Health-Related Quality of Life in Patients With Heart Failure |
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Authors: | Shoichiro Yatsu Takatoshi Kasai Shoko Suda Masaru Hiki Hiroki Matsumoto Sayaki Ishiwata Akihiro Sato Nanako Shiroshita Mitsue Kato Fusae Kawana Azusa Murata Megumi Shimizu Jun Shitara Takao Kato Eiryu Sai Naotake Yanagisawa Katsumi Miyauchi Hiroyuki Daida |
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Institution: | 1. Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan;2. Department of Cardiovascular Medicine, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan;3. Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;4. Sleep and Sleep Disordered Breathing Center, Juntendo University Hospital, Tokyo, Japan;5. Clinical Research and Trial Center, Juntendo University, Tokyo, Japan |
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Abstract: | BackgroundRestless legs syndrome (RLS) is a neurological disorder characterized by leg restlessness and dysesthesia. Although the relationship between RLS and heart failure (HF) has been reported, the prevalence and clinical significance of RLS in patients with HF remain to be elucidated.Methods and ResultsWe enrolled consecutive patients with HF who were admitted to our institutions. RLS was diagnosed using the International Restless Legs Syndrome Study Group criteria. Subjective sleepiness, sleep quality, and quality of life (QoL) were assessed using the Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), and 8-item Short Form (SF-8), respectively. Among the 133 patients, 18 (13.6%) had RLS and were younger than those without RLS (62.4±13.4 vs 70.0±12.2, P = .017). The RLS group had significantly disrupted sleep quality and QoL, with greater PSQI score (8.0±3.2 vs 5.9±3.3, P = .015) and lower SF-8 physical component summary (PCS) score (35.6±6.5 vs 40.7±9.5, P = .031), despite similar ESS and SF-8 mental component summary scores. In the multivariable regression analysis, RLS was associated with greater PSQI (β=0.211; P = .014) and lower PCS score (β=?0.177; P = .045).ConclusionIn the patients with HF, RLS was prevalent, and sleep quality and QoL may be disrupted by RLS. |
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Keywords: | Reprint requests: Takatoshi Kasai MD PhD Department of Cardiovascular Medicine Juntendo University School of Medicine Cardiovascular Respiratory Sleep Medicine Juntendo University Graduate School of Medicine Sleep and Sleep Disordered Breathing Center Juntendo University Hospital 3-1-3 Hongo Bunkyo-ku Tokyo Japan Tel: +81-33813-3111 Fax: +81-5689-0627 Restless legs syndrome heart failure sleep quality quality of life sleep |
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