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| 乙型肝炎病毒模型的方法学研究 | |
| 引用本文： | 张新全,黄正明,杨新波,曹文斌,陈红艳,刘贺之,李壮. 乙型肝炎病毒模型的方法学研究[J]. 解放军药学学报, 2005, 21(5): 360-363 |
| 作者姓名： | 张新全 黄正明 杨新波 曹文斌 陈红艳 刘贺之 李壮 |
| 作者单位： | 中国人民解放军第302医院,药学部药理研究室,北京,100039;中国人民解放军总医院老年医学研究所,药理研究室,北京,100853;中国人民解放军总后勤部卫生部药品仪器检验所,北京,100071;中国医学科学院医药生物技术研究所,病毒室,北京,100083 |
| 摘 要： | 目的在现有树鼩和雏鸭动物模型的基础上,对有关试验内容和方法加以改进,为研发抗乙肝病毒（HBV）新药提供比较理想的试验模型.方法采用乙肝病毒（HBV）分别感染树鼩和雏鸭造成肝细胞炎症,以血液生化、肝功能、血液及肝脏HBV-DNA水平、肝组织学的病理改变为观察指标,综合判断造模的程度.结果乙肝病毒（HBV）感染的树鼩和雏鸭动物模型,其检测指标灵敏,肝组织学改变明显.结论改进后的乙肝实验动物模型稳定,重复性好,适用于防治乙肝药物的应用研究. |
| 关 键 词： | 乙型肝炎 基础研究 实验模型 |
| 文章编号： | 1008-9926（2005）05-0360-04 |
| 收稿时间： | 2003-09-26 |
| 修稿时间： | 2005-04-08 |
Methods Study on the Model of Hepatitis B |
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| ZHANG Xin-Quan,HUANG Zheng-Ming,YANG Xin-Bo,CAO Wen-Bin,CHEN Hong-Yan,LIU He-Zhi,LI Zhuang. Methods Study on the Model of Hepatitis B[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2005, 21(5): 360-363 | |
| Authors: | ZHANG Xin-Quan HUANG Zheng-Ming YANG Xin-Bo CAO Wen-Bin CHEN Hong-Yan LIU He-Zhi LI Zhuang |
| Abstract: | Aim To explore and set up two kinds of experimental models of hepatitis B in order to provide varies methods for application study on drugs of prevention and cure hepatitis B. Methods According to the disorder of hepatitis B and character of hepatitis B infection, The elementary study markers were the changes of blood biochemistry, liver function, HBV - DNA of blood and liver, and liver histology. The model of hepatitis was infected by HBV. Results two models were set up. They are animal models of HBV infected models in vivo. The changes of blood biochemistry, liver function and liver histology are markers. Conclution The experimental models of hepatitis B which had been improved were steady and had good repeated nature. It can be used in the study of the drug for prevention and cure the hepatitis B. |
| Keywords: | Hepatitis B Basis study Experimental model |
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