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ABL amplification in a patient with lymphoid blast crisis of chronic myelogenous leukaemia |
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| Authors: | L. Kenner C. Beham-Schmid R. Kerbl H. H. Schmidt H. Sill G. Hoefler |
| Affiliation: | (1) Institute of Pathology, University of Graz, Auenbruggerplatz 25, A-8036 Graz. Austria E-mail: gerald.hoefler@kfunigraz.ac.at, Fax: +43-316 384329, AT;(2) Department of Paediatrics, University of Graz, Graz, Austria, AT;(3) Department of Internal Medicine, University of Graz, Graz Austria, AT |
| Abstract: | Although chronic phase myelogenous leukaemia (CML) is characterised by the Philadelphia (Ph) chromosome leading to a fusion of the BCR and ABL genes, additional genetic alterations involved in blast crisis are poorly understood. We report an at least 15-fold amplification of the ABL oncogene in a 29-year-old male patient with a variant Ph-positive t(19;22)(p13;q11.2) CML who presented in lymphoid blast crisis. Our finding suggests that an amplification of the ABL oncogene might play a part in the appearance of an aggressive phenotype in some cases of CML. Received: 27 July 1998 / Accepted: 26 October 1998 |
| Keywords: | BCR-ABL Amplification CML Blast crisis |
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