| 交链孢酚诱发人胚食管上皮癌的研究 |
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| 引用本文： | 刘桂亭,钱玉珍,杨红艳,宫亚欧,董子明,张鹏,秦秀生,赵琳阁,陈振光,马长路.交链孢酚诱发人胚食管上皮癌的研究[J].郑州大学学报(医学版),1990(2). |
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| 作者姓名： | 刘桂亭 钱玉珍 杨红艳 宫亚欧 董子明 张鹏 秦秀生 赵琳阁 陈振光 马长路 |
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| 作者单位： | 河南医科大学病理生理学教研室
(刘桂亭，钱玉珍，杨红艳，董子明，张鹏，秦秀生)，河南医科大学食管癌研究室
(宫亚欧)，河南医科大学病理学教研室
(赵琳阁，陈振光)，河南医科大学病理学教研室(马长路) |
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| 基金项目： | 国家科委资助课题，卫生部资助课题，河南省科委资助课题 |
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| 摘 要： | 将体外培养的水囊引产的人胎儿食管用交链孢酚(Alternariol,AOH)处理24h,再培养两周,分别接种于裸小鼠皮下和腹腔内。皮下接种的3个食管组织块中之一形成鳞状细胞癌,其余2个和接种于腹腔的2个食管组织块上皮细胞呈明显增生或乳头状增生。空白对照组的食管组织块未见增生。溶剂对照组者仅呈轻度增生。结果提示互隔交链孢霉在人食管癌病因学中起着重要作用。
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| 关 键 词： | 人胚 食管肿瘤 链格孢属 霉菌 肿瘤病因 裸小鼠 |
Study on the Induction of Esophageal Epithelial Cancer of Human Embryo by Alternariol |
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| Liu Guiting,Qian Yuzhen,Yang Hongyan,Gong Yaou,Dong Ziming,Zhang Peng,Qin Xiusheng,Zhao Linge,Chen Zhenguang,Ma Changlu.Study on the Induction of Esophageal Epithelial Cancer of Human Embryo by Alternariol[J].Journal of Zhengzhou University: Med Sci,1990(2). |
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| Authors: | Liu Guiting Qian Yuzhen Yang Hongyan Gong Yaou Dong Ziming Zhang Peng Qin Xiusheng Zhao Linge Chen Zhenguang Ma Changlu |
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| Institution: | Liu Guiting;Qian Yuzhen;Yang Hongyan;Gong Yaou;Dong Ziming;Zhang Peng;Qin Xiusheng;Zhao Linge;Chen Zhenguang;Ma Changlu Department of Pathophysiology Department of Pathology |
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| Abstract: | In this experiment, the tissue blocks of the esophagus of human embryoobtained by induced abortion with water ballon were cultural in vitro for oneweek, then treated with Alternariol (AOH) for 24 hours add were cultured foranother two weeks. Finally, the tissue blocks treated with AOH were inoculatedto the nude mice (BALB/C), 3 endermically and 2 in the abdominal cavities.Thetissue blocks inoculated endermically developed to squamocellular carcinoma in oneof the animals. In the other animale, all the tissue blocks showed obvious of pa-pillary proliferations. However, the blocks of the control group showed no proli-ferations at all; in the solvent control group, only slight proliferation was seen.There have been no reports on the induction of human embryo esophageal cancerwith toxins of Alternaria alternata at home and abroad. Our results give the sug-gestion that Alternaria alternata play a very important role in the etiology of humanesophageal cancer. |
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| Keywords: | human embryo esophageal cancer Alternaria fungus tumor etiology nude mice |
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