| 瞬时弹性成像与非酒精性脂肪性肝病病理纤维化分期的相关性 |
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| 引用本文： | 范丽娟,廖慧钰,姜太一,黄云丽,刘燕敏.瞬时弹性成像与非酒精性脂肪性肝病病理纤维化分期的相关性[J].世界华人消化杂志,2012(17):1515-1519. |
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| 作者姓名： | 范丽娟 廖慧钰 姜太一 黄云丽 刘燕敏 |
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| 作者单位： | 首都医科大学附属北京佑安医院肝病免疫科;首都医科大学附属北京佑安医院感染科 |
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| 摘 要： | 目的:评价瞬时弹性成像(Fibroscan,FS)在非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)肝纤维化诊断中的作用.方法:选取2008-04/2011-02在北京佑安医院住院,且经病理检查诊断为NAFLD的患者83例,临床检测肝功能、空腹血糖、血脂、尿酸,同时应用FS进行肝脏硬度检测.以病理检查结果为金标准,分析肝脏硬度、生化学指标及病理肝纤维化程度的相关性,采用受试者工作特征(ROC)曲线分析FS诊断NAFLD肝纤维化的准确性.结果:不同程度肝纤维化分期的肝脏硬度值,S0期:4.28kPa±1.32kPa,S1期:7.40kPa±2.13kPa,S2期:11.52kPa±3.86kPa,S3期:19.99kPa±5.42kPa.肝脏硬度与肝纤维化程度呈正相关,Spearman相关系数为0.768,P<0.001.Pearson相关分析显示,FS肝脏硬度检测值与ALT、AST呈正相关,与HDL、ApoA呈负相关(P<0.05).FS诊断S0-S1、S2、S3期的ROC曲线下面积分别为0.889(0.813,0.965)、0.838(0.729,0.948)、0.938(0.000,1.000),诊断界值分别为8.95kPa、10.60kPa、15.66kPa.结论:FS对NAFLD肝纤维化有较高的诊断价值,可作为NAFLD患者诊断和动态随访的依据.
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| 关 键 词： | 瞬时弹性成像 肝纤维化 诊断设备 诊断 非酒精性脂肪性肝病 |
Correlation between liver stiffness measurement by Fibroscan and liver fibrosis staging based on a liver biopsy in patients with NAFLD |
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| Li-Juan Fan,Hui-Yu Liao,Yun-Li Huang,Yan-Min Liu.Correlation between liver stiffness measurement by Fibroscan and liver fibrosis staging based on a liver biopsy in patients with NAFLD[J].World Chinese Journal of Digestology,2012(17):1515-1519. |
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| Authors: | Li-Juan Fan Hui-Yu Liao Yun-Li Huang Yan-Min Liu |
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| Institution: | ,Department of Hepatology-Immunology,Beijing Youan Hospital Affiliated to Capital Medical University,Beijing 100069,China Tai-Yi Jiang,Department of Infectious Diseases,Beijing Youan Hospital Affiliated to Capital Medical University,Beijing 100069,China |
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