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| 450例宫颈活检组织中人乳头瘤病毒的分布特征 | |
| 引用本文： | 王翔,钱福初,顾栋桦,秦基取,陈瑜,李雄峰. 450例宫颈活检组织中人乳头瘤病毒的分布特征[J]. 浙江中医药大学学报, 2011, 35(2): 146-147,150 |
| 作者姓名： | 王翔 钱福初 顾栋桦 秦基取 陈瑜 李雄峰 |
| 作者单位： | 1. 温州医学院,温州,325035;浙江省湖州市中心医院 2. 浙江省湖州市中心医院 3. 温州医学院,温州,325035;浙江大学医学院附属第一医院 4. 浙江中医药大学 |
| 摘 要： | [目的]了解阴道镜检查患者的宫颈活检组织中HPV的感染率和亚型分布。[方法]对宫颈脱落细胞学异常的患者450例进行阴道镜下定位活检。活检组织同时行HPV基因分型和病理诊断,HPV基因分型采用斑点杂交方法进行。[结果]在450例宫颈活检患者中,其HPV感染率为65.3%。在HPV-DNA阳性患者中,检出率最高的HPV-16占36.7%,依次HPV-58为22.1%、HPV-18为18.7%、HPV-52为16.0%。在宫颈炎、CINⅠ、CINⅡ、CINⅢ中HPV-DNA阳性率分别为55.6%、69%、82.7%和88.9%。在宫颈炎、CINⅠ、CINⅡ,CINⅢ组织中均检测到HPV-16、-58、-18和-52。[结论]本研究中的宫颈活检组织中不仅检测到HPV-16和-18,还检测到HPV-58和-52感染,后者的发现为开发宫颈癌多价复合型疫苗提供了事实依据。 |
| 关 键 词： | 人乳头瘤病毒 宫颈活检 HPV基因分型 |
The Distribution and Infection of HPV in Cervical Biopsy Lesions among 450 Women |
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| Wang Xiang,Qian Fuchu,Gu Donghua,et al Wenzhou Medical College,Zhejiang,China. The Distribution and Infection of HPV in Cervical Biopsy Lesions among 450 Women[J]. Journal of Zhejiang University of Traditional Chinese Medicine, 2011, 35(2): 146-147,150 | |
| Authors: | Wang Xiang Qian Fuchu Gu Donghua et al Wenzhou Medical College Zhejiang China |
| Affiliation: | Wang Xiang,Qian Fuchu,Gu Donghua,et al Wenzhou Medical College,Zhejiang(325025),China |
| Abstract: | [Objective] To determine the distribution and infection of HPV in cervical cancer and precancerous lesions.[Methods] Four hundred patients with abnormal cytology were examined by colposcopy.HPV diagnosis was done by polymerase chain reaction using MY09/MY11 primers,for genotyping blot hybridization was used.The pathological results confirmed standards.[Result]A total of 294 women were HPV-DNA positive.HPV-16 was found in 36.7% of all women with positive HPV-DNA,HPV58 in 22.1%,HPV-18 in 18.7% and HPV-52 in 1... |
| Keywords: | human papillomavirus cervical biopsy HPV gene typing |
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