慢性阻塞性肺病患者CRR、CK-MB和BNP水平的改变及临床意义

目的 探讨血清C-反应蛋白(CRP)、磷酸肌酸激酶同工酶(CK-MB)和B型利钠肽(BNP)在慢性阻塞性肺病(COPD)急性发作期和治疗缓解期浓度变化及临床意义.方法 测定90例COPD患者急性发作期、治疗缓解期血清CRP、CK-MB和BNP水平和动脉血氧分压(PaO2),60例健康体检者血清CRP、CK-MB和BNP...

Changes of serum CRP, CK-MB and BNP levels in COPD patient and its clinical significance

Objective To investigate the changes of serum C-reactive protein （CRP）, creatine kinase MB isoenzyme （CK-MB） and brain natriuretic peptide （BNP） levels and their clinical significance in patients with chronic obstructive pulmonary disease （COPD）. Methods Serum CRP, CK-MB, BNP and PaO2 levels were measured in 90 patients with COPD at acute exacerbation and remission stage, and 60 healthy subjects （controls）. Results Serum CRP, CK-MB, and BNP levels of COPD patients in the acute exacerbation and remission stage were higher than those in healthy controls （P 〈 0.05）. Serum CRP, CK-MB, and BNP levels of COPD patients in the acute exacerbation were higher than those in remission stage （P 〈 0.05）. PaO2 levels of COPD patients in the acute exacerbation were significantly lower than those in remission stage （P〈 0.05）. There was positive correlation of serum CRP of COPD patients in acute exacerbation with CK-MB and BNP levels, and positive correlation of serum CK-MB with BNP （r=0.389,0.284,0.268;P=0.000,0.007,0.011）. There was negative correlation of PaO2 with serum CRP, CK-MB and BNP （r=-0.220,-0.254, -0.317 ;P=0.037,0.016,0.002 ）. However, there was no such correlations in COPD patients at remission stages. Conclusion combined detection of serum CRP, CK-MB and BNP can provide reliable indicators for diagnosis, prevention and treatment of COPD.