Stereoselective analysis of the disposition of tosufloxacin enantiomers in man |
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Authors: | R Minami N Inotsume C Nakamura M Nakano |
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Institution: | (1) Department of Pharmacy, Kumamoto University Hospital, Honjo, Kumamoto, Japan |
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Abstract: | Summary The pharmacokinetics of tosufloxacin enantiomers after oral administration of racemic tosufloxacin were examined in healthy volunteers. Only small differences were observed in time to peak concentration (2.6±0.3 mean ± SEM] h for (+)-tosufloxacin vs 2.4±0.2 h for (–)-tosufloxacin), elimination half-life (3.61±0.24 h vs 3.49±0.23 h), and area under the curve (2.78±0.19 h·g/ml vs 2.87±0.19 h·g/ml); however, peak concentration (0.40±0.03 g/ml vs 0.44±0.03 g/ml), renal clearance (226±10 ml/min vs 202±10 ml/min), and urinary recovery (35.4±2.2% vs 32.4±1.9%) differed significantly between enantiomers. |
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Keywords: | Tosufloxacin Enantiomer pharmacokinetics |
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