中西医结合对反流性食管炎患者食管动力学的影响研究

目的 探讨中西医结合对反流性食管炎患者食管动力学的影响.方法 反流性食管炎患者80例随机分为实验组和对照组,每组40例.对照组口服雷贝拉唑肠溶胶囊,实验组在对照组基础上口服枳术宽中胶囊,两组均连续服用8周.两组治疗总有效率比较,治疗前后食管动力学变化,不良反应和复发情况.结果 实验组总有效率(92.50％)高于对照组(70.00％),差异有统计学意义(P＜0.05);实验组患者治疗后食管括约肌压力(2.98±0.47) kPa高于对照组(2.21±0.43) kPa,立位反流时间百分比(2.28±0.47)％和卧位反流时间百分比(2.09±0.56)％低于对照组立位反流时间百分比(4.19±0.59)％和卧位反流时间百分比(6.17±1.08)％,差异均有统计学意义(均P＜ 0.05);两组患者用药8周期间均未出现明显药物不良反应;实验组复发率(10.00％)低于对照组(32.50％),且差异有统计学意义(P＜0.05).结论 中西医结合治疗反流性食管炎患者疗效明显,且可改善患者食管动力学.

Effect of integrated traditional Chinese and western medicine on esophageal dynamics in patients with reflux esophagitis

Objective To investigate the effect of integrated traditional Chinese and western medicine on esophageal dynamics in patients with reflux esophagitis.Methods 80 cases of reflux esophagitis were randomly divided into experimental group and control group,40 cases in each group.The control group was treated with rabeprazole enteric capsules,and the experimental group was treated with Zhizhukuanzhong capsules on the basis of the control group.The two groups were treated for 8 weeks.The total effective rate,the changes of esophageal dynamics before and after treatment,adverse reactions,and recurrence were compared between the two groups.Results The total efficiency of the experimental group (92.50％) was higher than that of the control group (70.00％) (P＜0.05).Esophageal sphincter pressure of the experimental group after the treatment was higher than that of the control group [(2.98±0.47)kPa vs.(2.21±0.43)kPa,P＜0.05].The percentages of acid exposure time at erect position and lying position of the experimental group were lower than those of the control group [(2.28±0.47)％ vs.(4.19±0.59)％,(2.09±0.56)％ vs.(6.17±1.08)％;P＜0.05].There were no significant adverse drug reactions in two groups during the 8 weeks.The recurrence rate of the experimental group was lower than that of the control group (10.00％ vs.32.50％,P＜0.05).Conclusion Integrated traditional Chinese and western medicine in the treatment of reflux esophagitis has obvious curative effect,which can improve the esophageal dynamics of patients.