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影响新生儿坏死性小肠结肠炎手术疗效的因素探讨
引用本文:王俊平,刘颖,张永,朱小春,葛午平,杨杰,陈运彬. 影响新生儿坏死性小肠结肠炎手术疗效的因素探讨[J]. 国际医药卫生导报, 2017, 23(3). DOI: 10.3760/cma.j.issn.1007-1245.2017.03.002
作者姓名:王俊平  刘颖  张永  朱小春  葛午平  杨杰  陈运彬
作者单位:广东省妇幼保健院新生儿科, 广州,511442
基金项目:广东省医学科学技术研究基金(A2014100)Fund of Research of Medical Science and Technology in Guangdong
摘    要:
目的 探讨影响新生儿坏死性小肠结肠炎(NEC)手术疗效的临床及代谢因素.方法 回顾分析本院2010年1月至2014年12月5年间收治的NEC患儿的临床资料,并比较各种临床资料及代谢指标对NEC手术患儿预后的影响.结果 单因素分析结果发现气腹、血小板降低、CRP升高、腹膜炎、肠梗阻等5个因素P≤0.2,将此5个因素作为待选变量引入到回归方程,结果显示血小板降低及CRP升高是NEC手术失败的独立危险因素.结论 CRP与血小板计数,可作为预测NEC手术预后的指标之一.

关 键 词:坏死性小肠结肠炎  外科治疗  预后  新生儿

Factors influencing effect of surgery for neonatal necrotizing enterocolitis
Wang Junping,Liu Ying,Zhang Yong,Zhu Xiaochun,Ge Wuping,Yang Jie,Chen Yunbin. Factors influencing effect of surgery for neonatal necrotizing enterocolitis[J]. International Medicine & Health Guidance News, 2017, 23(3). DOI: 10.3760/cma.j.issn.1007-1245.2017.03.002
Authors:Wang Junping  Liu Ying  Zhang Yong  Zhu Xiaochun  Ge Wuping  Yang Jie  Chen Yunbin
Abstract:
Objective To explore the factors influencing the effect of surgery for neonatal necrotizing enterocolitis (NEC).Methods The clinical data of 102 cases of NEC treated at our hospital from January,2010 to December,2014 and were retrospectively analyzed.The factors influencing the prognosis were analyzed and compared.Results Univariate analysis found that pneumoperitoneum,thrombocytopenia,the increase of CRP,peritonitis,intestinal obstruction etc.five factors P ≤ 0.2;these five factors as candidates for variables were put into the regression equation,and the results show that thrombocytopenia and the increase of CRP were independent risk factors for the effects of surgical therapy on NEC.Conclusions Platelet count and CRP should be monitored as the predictive factors for NEC patients especially for those who need operation.
Keywords:Necrotizing enterocolitis  Surgical treatment  Prognosis  Newborns
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