阿司匹林、肝素联合预防性抗凝治疗复发性流产的疗效分析

目的 探讨阿司匹林、肝素联合预防性抗凝治疗对复发性流产患者的临床治疗效果.方法 收集2015年1月至2016年1月入院的100例复发性流产患者随机分为两组,对照组患者给予传统治疗,实验组患者则加施阿司匹林、肝素联合的预防性抗凝治疗,比较两组患者治疗前后相关临床指标、妊娠结局、并发症与药物不良反应发生率.结果 实验组患者治疗后血小板计数(PLT)(185.25±2.07)×109/L]、凝血酶原时间(PT)(10.31±0.29)s]、活化部分凝血酶时间(APTT)(30.12±0.67)s]、纤维蛋白原(FIB)(2.20±0.33) g/L]与纤溶酶原激活物抑制剂-1(PAI-1)水平(0.58±0.15) AU/ml]均显著低于对照组(189.75±2.13)×109/L、(11.60±0.35)s、(33.31±0.70)s、(2.95±0.47)g/L、(1.01±0.22)AU/ml],血浆组织型纤溶酶原活化因子(T-PA)水平(0.61±0.17) U/ml]显著高于对照组(0.43±0.14)U/rnl];抗心磷脂抗体清除率显著高于对照组(70.00％比33.33％),两组比较差异有统计学意义(P＜0.01);活产率明显高于对照组(88.00％比68.00％),流产率明显低于对照组(12.00％比28.00％),总体妊娠期并发症发生率明显低于对照组(20.00％比42.00％),差异有统计学意义(P＜0.05);两组患者总体药物不良反应发生率不存在明显差异(22.00％比18.00％),差异无统计学意义(P＞0.05).结论 阿司匹林、肝素联合的预防性抗凝治疗对复发性流产患者的临床治疗效果显著,安全性较高,借鉴意义重大.

Efficacy of aspirin,heparin anticoagulant prophylactic treatment for recurrent spontaneous abortion

Objective To investigate clinical efficacy of aspirin,heparin anticoagulant prophylactic treatment for recurrent spontaneous abortion.Methods 100 cases of recurrent spontaneous abortion from January 2015 to January 2016 were randomly divided into two groups,the control group was treated with conventional therapy,the experimental group was additionally given aspirin,heparin anticoagulant prophylactic treatment.The related clinical parameters before and after treatment,pregnancy outcomes,complications,and the incidence of adverse drug reactions of two groups were compared.Results After treatment,the levels of PLT (185.25±2.07)×109/L],PT (10.31±0.29)s],APTT (30.12±0.67)s],FIB (2.20±0.33) g/L],and PAI-1 (0.58±0.15) AU/ml] in the experimental group were significantly lower than those in the control group (189.75±2.13)× 109/L,(11.60±0.35)s,(33.3 1±0.70)s,(2.95±0.47)g/L,(1.01±0.22)AU/ml],T-PA level (0.61±0.17)U/ml] was significantly higher than that in the control group (0.43±0.14)U/ml].The clearance rate of anticardiolipin antibody,the live birth rate in the experimental group were significantly higher than those in the control group (70.00％ vs.33.33％,88.00％ vs.68.00％),the rate of abortion,the overall rate of gestation complications were significantly lower than those in the control group (12.00％ vs.28.00％,20.00％ vs.42.00％),there was no statistically significant difference in the incidence of adverse drug reactions between the two groups (22.00％ vs.18.00％,P＞0.05).Conclusion Aspirin,heparin anticoagulant prophylactic treatment has significant clinical effect in patients with recurrent spontaneous abortion,with high security,drawing on great significance.