基于在位和异位内膜Bcl-w蛋白表达的子宫内膜异位症机制探讨

目的 探讨凋亡抑制基因Bcl-w在子宫内膜异位症的发生发展中的作用.方法 采用免疫组织化学染色法(SP法)检测凋亡抑制基因Bcl-w分别在正常子宫内膜组织、子宫内膜异位症患者的异位内膜组织和在位内膜组织中的表达水平.结果 Bcl-w在子宫内膜的腺上皮细胞和间质细胞中均有表达,以腺上皮细胞浆中表达明显,偶有细胞膜和细胞核表达.异位子宫内膜组和在位子宫内膜组Bcl-w的表达高于正常子宫内膜组,差异有统计学意义(均P＜ 0.01);Bcl-w在异位子宫内膜组的表达高于在位子宫内膜组,差异有统计学意义(P＜0.05).结论 凋亡抑制基因Bcl-w在子宫内膜异位症的发生发展中起着很重要的作用.

Mechanism of endometriosis based on the expressions of Bcl-w protein in eutopic and ectopic endometrium

Objective To investigate the role of apoptosis suppressing gene——Bcl-w in the morbidity and development of endometriosis (EMT).Methods Immunohistochemical staining (SP method) was used to detect the expressions of Bcl-w in endometrium tissues in normal endometrium and EMT in both eutopic and ectopic endometrium,respectively.Results Bcl-w was expressed in the glandular epithelial cells and stromal cells of the endometrium,especially in the cytoplasm of glandular epithelial cells and occasionally in cytomembranes and cell nuclei.The expressions of Bcl-w in the ectopic endometrium group and the eutopic endometrium group were higher than that in the normal endometrium group (P ＜ 0.01).The expression of Bcl-w in the ectopic endometrium group was higher than that in the eutopic endometrium group (P ＜ 0.05).Conclusion Bcl-w,an apoptosis inhibiting gene,plays an important role in the morbidity and development of EMT.