相关自身抗体在女性不孕患者中的检测意义

目的探讨女性不孕患者血清中不孕五项相关自身抗体在免疫性不孕症中的检测意义。方法采用酶联免疲吸附试验测定168例女性不孕患者血清中的抗精子抗体、抗HCG抗体、抗卵巢抗体、抗心磷脂抗体和抗子宫内膜抗体。同时测定健康已育者66例作为对照组。结果在168例女性不孕患者中，血清抗精子抗体、抗HCG抗体、抗卵巢抗体、抗心磷脂抗体和抗子宫内膜抗体的阳性例数分别为29、3、6、2和5，阳性率分别为17．3％、1．8％、3．6％、1．2％和3．O％。在66例对照组中，上述抗体的阳性例敷分别为2、O、0、O和l，阳性率分别为3.0％、0,0、0和1．5％。经卡方分析，不孕组抗精子抗体阳性率明显高于正常对照组（P〈0．05）。不孕组抗HCG抗体、抗卵巢抗体、抗心磷脂抗体和抗子宫内膜抗体阳性率高于正常对照组，但是差异无统计学意义（P〉0．05）。结论抗精予抗体是女性最重要的免疫性不孕因素。检测血清不孕五项相关自身抗体有助于临床免疫性不孕症的诊断。

The Significance of Detecting Related Autoantibodies In Infertile Women

Objective To investigate the significance of 5 kinds of female infertilit3, - related autoantibodies from the serum of patients with infertihty. Methods Anti - sperm antibodies, anti- HCG antibody, anti- ovarian antibodies, antieardiolipin antibodies and anti - endometrial antibodies were analyzed by ELISA in serum from 168 female infertlity ease, and 66 healthy persons had given birth as a control group. Re- suits The positive eases of anti - sperm antibody, anti- HCG antibody, anti- ovarian antibody, anti- eardialipin antibody and anti- endometrial antibody in serum were 29,3,6,2 and 5 in 168 eases of female infertility.The positive rates were 17.3%, 1.8%, 3.6% , 1.2% and 3. 0% . The positive eases of anti - sperm antibody, anti - HCG antibody, anti - ovarian antibody, anti - eardiolipin antibody and anti - endome- trial antibody in serum were 2,0,0,0 and 1 in 66 eases of normal control group.The positive rates were 3.0% ,0,0,0 and 1.5% .The positive rate of anti - sperm antibody in infertile group was sigrtifleantly higher than the control group （ P 〈 0.05）. The positive rates of anti - HCG anti- body, anti - ovarian antibody, anti - eardiolipin antibody and anti- endometrial antibody in infertile group were higher than the control group, but the difference were not statistically significant （ P 〉 0.05）. Conclusions The anti - sperm antibodies is one of the most important immune female infertility factors. It is helpful to detet those 5 kinds of female infertilityrelated autoantibodies for the elinieal diagnosis of immune infer- tility.