Virus-specific sequences within restriction DNA fragments of cells persistently infected with tick-born encephalitis virus |
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| Authors: | I. D. Drynov V. V. Nosikov L. V. Uryvaev N. N. Bogomolova V. M. Zhdanov |
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| Affiliation: | (1) The D. I. Ivanovsky Institute of Virology, The U.S.S.R. Academy of Medical Sciences, Moscow, USSR;(2) Institute of Viral Preparations, The U.S.S.R. Ministry of Health, Moscow, USSR |
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| Abstract: | ![]()
Summary Using the Southern blot technique and a32P-labelled DNA copy of RNA TBEV as a probe, we studied the state of proviral DNA sequences in nuclear DNA of cells persistently infected (p.i.) with TBEV. Integration of virus-specific DNA sequences in DNA of p.i. was demonstrated. Discrete bands were observed, suggesting the existence of limited and specific intergration sites in host cellular DNA.With 1 Figure |
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