A convenient method for the preparation of 99mTc(V)dimercaptosuccinic acid (99mTc(V)-DMSA) |
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| Authors: | G Westera A Gadze W Horst |
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| Affiliation: | 1. Department of Forensic Sciences, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway;2. Department of Chemistry, University of Oslo, Oslo, Norway;1. Analytical Chemistry Group, Van ‘t Hoff Institute for Molecular Sciences, University of Amsterdam, the Netherlands;2. Centre for Analytical Sciences Amsterdam (CASA), the Netherlands;3. Dow, Core R&D Analytical Science, 65201 Wiesbaden, Germany;4. Department of Chemistry, Gustavus Adolphus College, Saint Peter, Minnesota 56082, United States;1. Pharmacokinetics and Toxicology Laboratory, Toulouse University Hospital, Toulouse, France;2. CHU Limoges, P&T, INSERM UMR1248, University of Limoges, Limoges, France;1. Quantitative Biology, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, United States;2. Cancer Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, United States |
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| Abstract: | ![]()
Tc(IV)-DMSA for kidney scintigraphy has been prepared in acidic solution. Once the labeling is done in basic solution, upon addition of a small amount of NaHCO3, a mixture of 3-4 other DMSA-complexes is formed, presumably containing Tc(V). Kidney uptake in male adult rats of the 99mTc(V)-DMSA is 1.6% injected dose/g (4.9%/total organ) compared to 16.4% injected dose/g (resp. 50.3%/total organ) for 99mTc(IV)-DMSA. |
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