| K-CoxB-JN复方总多糖对阿霉素心肌损伤小鼠心肌酶的影响 |
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| 引用本文： | 王敏,储金秀,韩淑英,张博男,吴范武,包巨太. K-CoxB-JN复方总多糖对阿霉素心肌损伤小鼠心肌酶的影响[J]. 辽宁中医杂志, 2011, 0(7): 1441-1443 |
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| 作者姓名： | 王敏 储金秀 韩淑英 张博男 吴范武 包巨太 |
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| 作者单位： | 华北煤炭医学院; |
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| 基金项目： | 国家科技重大专项课题(重大新药创制)(2009ZX09103-442) |
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| 摘 要： | 目的:探讨抗柯萨奇B病毒性心肌炎胶囊(K-CoxB-JN)复方总多糖(polysaccharide)对阿霉素(ADM)致心肌损伤小鼠心肌酶的影响。方法:注射ADM建立小鼠心肌损伤模型,随机平均分为7组,正常组,模型组,多糖高、中、低剂量组(给药剂量分别为4.4g/kg,2.2g/kg,1.1g/kg),原方水煎组(6g/kg)和心血康组(0.1g/kg),分别灌胃给予相应的药物,每天1次。给药第8天造模,24h后摘除眼球取血处死全部小鼠检测AST、ALT、CK、LDH、HBDH。结果:模型组五项心肌酶指标明显高于正常组(P<0.01)。与模型组比较各药物治疗组五项心肌酶有不同程度的降低,其中多糖高剂量组心肌酶明显降低(P<0.01)。结论:多糖对心肌损伤小鼠心肌酶的有抑制作用,呈现明显的量效关系。
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| 关 键 词： | K-CoxB-JN 总多糖 阿霉素 心肌酶 |
K-CoxB-JN Polysaccharide Compound on Myocardial Injury Induced by Myocardial Enzyme |
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| WANG Min,CHU Jin-xiu,HAN Shu-ying,ZHANG Bo-nan,WU Fan-wu,BAO Ju-tai. K-CoxB-JN Polysaccharide Compound on Myocardial Injury Induced by Myocardial Enzyme[J]. Liaoning Journal of Traditional Chinese Medicine, 2011, 0(7): 1441-1443 |
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| Authors: | WANG Min CHU Jin-xiu HAN Shu-ying ZHANG Bo-nan WU Fan-wu BAO Ju-tai |
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| Affiliation: | WANG Min,CHU Jin-xiu,HAN Shu-ying,ZHANG Bo-nan,WU Fan-wu,BAO Ju-tai(North China Coal Medical College Department,Tangshan 063000,Hebei,China) |
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| Abstract: | Objective:To investigate the anti-Coxsackie B viral myocarditis capsule(K-CoxB-JN) with polysaccharide on adriamycin(ADM) which induced myocardial injury in mice with myocardial enzymes.Methods:Mice injected with ADM model of myocardial injury,were randomly divided into 7 groups,the normal group,model group,polysaccharides of high,medium and low dose group(administered dose of 4.4g/kg,2.2g/kg,1.1g/kg),the original party decoction group(6g/kg) and Xinxuekang group(0.1g/kg),given the appropriate drugs which w... |
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| Keywords: | K-CoxB-JN polysaccharide adriamycin enzyme |
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