| HPLC法测定布洛芬缓释胶囊有关物质 |
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| 引用本文： | 贺秀婷,翟光喜,皇甫传青,刘云. HPLC法测定布洛芬缓释胶囊有关物质[J]. 齐鲁药事, 2013, 0(2): 85-87 |
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| 作者姓名： | 贺秀婷 翟光喜 皇甫传青 刘云 |
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| 作者单位： | 山东大学药学院;山东新华制药股份有限公司 |
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| 摘 要： | 目的建立布洛芬缓释胶囊有关物质的高效液相色谱测定方法。方法 Eclipce XDB C18柱,0.076%磷酸溶液-乙腈(66:34)为流动相,流速为1.5 mL.min-1,柱温40℃,检测波长为214 nm。结果布洛芬在0～80.192μg.mL-1范围内浓度与峰面积线性关系良好,相关系数r=0.999 9(n=9)。结论该方法简单,快速,准确,分离效果好,能作为布洛芬缓释胶囊有关物质的测定方法。
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| 关 键 词： | 布洛芬缓释胶囊 有关物质 高效液相色谱法 |
Determination of related substances in Ibuprofen Sustained-release Capsules by HPLC |
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| HE Xiu-ting,ZHAI Guang-xi,HUANG PU Chuan-qing,LIU Yun. Determination of related substances in Ibuprofen Sustained-release Capsules by HPLC[J]. qilu pharmaceutical affairs, 2013, 0(2): 85-87 |
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| Authors: | HE Xiu-ting ZHAI Guang-xi HUANG PU Chuan-qing LIU Yun |
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| Affiliation: | 1.School of Pharmaceutical Scineces,Shandong University,Jinan 250012,China;2.Shandong Xinhua Pharmaceutical Co.,Ltd.,Zibo 255005,China) |
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| Abstract: | Objective To establish an HPLC method for the determination of related substances in Ibuprofen Sustained-release Capsules.Methods The Eclipse XDB C18 column was used.The mobile phase was 0.076% phosphoric acid solution-acetonitrile=66∶ 34,the flow rate was 1.5 mL·min-1.The detection wavelength was 214 nm.Results The linear range of Ibuprofen Sustained-release Capsules was 0~80.192 μg·mL-1,r=0.999 9(n=9).Conclusion The method was simple,quickly,accurate and good resolution.It can provided a new and reliable means for the quality control to determination of Ibuprofen Sustained-release Capsules. |
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| Keywords: | Ibuprofen Sustained-release Capsules Related Substances RP-HPLC |
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