The conjugation of an AQP1-directed immunotoxin in the study of site-directed therapy within the CNS |
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| Authors: | Surash Surash Peter Nemeth Aruna Chakrabarty Paul Chumas |
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| Affiliation: | (1) Department of Neurosurgery, The General Infirmary at Leeds, Great George Street, Leeds, LS1 3EX, UK;(2) Department of Immunology and Biotechnology, University of Pecs, Pecs, Hungary;(3) Department of Neuropathology, The General Infirmary at Leeds, Great George Street, Leeds, LS1 3EX, UK |
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| Abstract: | Purpose The water channel, aquaporin (AQP)1, is highly specific to the choroid plexus (CP) epithelium within the brain. It is therefore a potential target through which therapeutic agents could be selectively directed to the CP. Here we describe the conjugation of a monoclonal antibody (mAb), raised against an extra-cellular domain of AQP1, to the A chain of ricin (RCA). This reagent should allow study of a highly specific chemical lesion of the CP. |
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