炎性细胞因子在脑外伤继发性脑损害中的作用及研究进展

脑外伤炎性反应在继发性脑损害中起重要作用。细胞因子作为体内重要的炎性介质,参与多种病理生理过程,在脑损伤后的炎症级联反应中起着重要的作用。核因子κB(NFκ-B)、肿瘤坏死因子α(TNFα-)、可溶性细胞间黏附分子1、血管内皮黏附分子1和白细胞介素1β(IL-1β)、IL-6、IL-8、IL-16等是几种主要的促炎性细胞因子,IL-2、IL-4、IL-10、IL-13等是抗炎性细胞因子,两类细胞因子参与了脑创伤后的继发性脑损伤及损伤修复。

Effects and Research Advancement of Inflammatory Cytokines in Brain Damage after Traumatic Brain Injury

Inflammatory reactions plays an important role in secondary traumatic brain injury(TBI).Being important inflammatory mediators,cytokines participate in many pathophysiologic processes and have significant function in inflammatory cascade reactions.NF-κB,TNF-α,sICAM-1,VCAM-1and IL-1β,IL-6,IL-8,IL-16 and so on are main proinflammatory cytokines,IL-2,IL-4,IL-10,IL-13and so on are antiinflammatory factors,both of which participate in nerve cell repair after TBI and protect brain tissues effectively.