2型糖尿病动物模型研究概况

动物模型在2型糖尿病研究中发挥了重要作用。实验性动物模型应用普遍,因其价格便宜,易于诱导和维持。自发动物模型更接近人类疾病发展过程,但价格昂贵,饲养繁殖要求较高。转基因动物和基因剔除模型可用于研究特定基因以及基因-环境在2型糖尿病发展中的交互作用,但操作复杂,价格昂贵,不能普遍推广。至今尚无一种模型能完全模拟出人类2型糖尿病的特征和发病机制。研究者应根据研究目的、实验条件选择合适的模型进行实验。

Overview of Type 2 Diabetes Mellitus Animal Models

Animal models have contributed enormously to the study of diabetes mellitus.The popularity of using experimentally induced diabetes models is attributed to the comparatively lower cost and simplicity of induction and maintenance.Spontaneous diabetes animal models are more similar to human disease,which is more costly and requires advanced breeding conditions.Transgenic and knockout diabetes animal models provide an excellent opportunity for investigating the role of specific gene products and gene-environme...