结直肠癌肝转移的啮齿动物模型建立的研究进展

50％～ 60％的Ⅱ～Ⅲ期结直肠癌患者发生了肝转移,如何改善结直肠癌肝转移患者的预后是近年来国际上的研究热点.通过建立结直肠癌肝转移的动物模型是研究肿瘤细胞如何形成肝转移的理想手段.理想的结直肠癌肝转移动物模型应该可以完全模仿肿瘤细胞在人体中转移的过程,包括细胞学行为的改变及肿瘤生物学的发展.此外,此模型应该是可实现的、有肿瘤警示意义及符合伦理规范的.至今,仍没有一个理想模型可以完全符合上述所有条件.本综述主要分析对比各结直肠癌肝转移啮齿动物模型建立的优缺点.

Review research: animal models for colorectal carcinoma liver metastases in rodents

About 50％ to 60％ of the stage Ⅱ-Ⅲ colorectal carcinoma patient suffer from liver metastases.Recently,there is a research hotspot on how to improve the prognosis of the colorectal carcinoma liver metastases (CRLM) patient.It can elucidate the way how the carcinoma cells transfer from the original tumor to the liver,through establishing a CRLM animal model.An ideal CRLM animal model should perfectly mimic the total procedure of the metastases pathway,including the change of the cytology behavior and the development of the tumor biology.Besides,the model should be practical,tumor-predictable and accord with the ethical consideration.Until now,there is not an ideal CRLM animal model can perfectly match those conditions.This review goes through the advantages and disadvantages of different CRLM animal model methods used for research.