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| 应用于多组分中药制剂释药评价的基于数学集合的释放动力学评价方法与Kalman滤波法的比较研究 | |
| 引用本文： | 沈岚,翟宇,马诗瑜,林晓,冯怡,阮克峰. 应用于多组分中药制剂释药评价的基于数学集合的释放动力学评价方法与Kalman滤波法的比较研究[J]. 中国中药杂志, 2013, 38(8): 1165-1171 |
| 作者姓名： | 沈岚 翟宇 马诗瑜 林晓 冯怡 阮克峰 |
| 作者单位： | 1. 上海中医药大学中药学院,上海201203;中药现代制剂技术教育部工程研究中心,上海201203 2. 上海中医药大学中药学院,上海,201203 3. 中药现代制剂技术教育部工程研究中心,上海,201203 |
| 基金项目： | 上海市科委科技攻关计划项目(08DZ1971100);上海市教委重点学科项目(J50302);上海市科委2012年度"科技创新行动计划"项目(12401900402);上海市教委创新项目(12ZZ124) |
| 摘 要： | 目的:提供一种评价多组分中药的基于数学集合的释药动力学方法.方法:以扶正化瘀方为研究模型,通过建立的基于数学集合的释放动力学评价方法指导扶正化瘀复方释药系统的制备,对其多组分释放特征进行量化评价,并采用Kalman滤波法验证方法的准确性.结果:两者比较结果均表明,扶正化瘀复方释药系统样本4与参比制剂扶正化瘀胶囊显示出释药同步.结论:此结果不仅验证了基于集合的方法的准确性和合理性,而且通过异步系数参数整体表征目标制剂的释放情况,并能从各特征峰信息的相对误差参数中找到释药单元剂量调整改进的方向,指导相关成分有目的性地调整,以使目标制剂满足与参比制剂释药同步性的要求,同时为多组分中药复方制剂的定量表征和评价中药多组分释放行为的同步性提供一种行之有效的评价手段. |
| 关 键 词： | 中药 多组分 释药同步性评价方法 释药集合 Kalman滤波法 |
| 收稿时间： | 2012-10-23 |
Comparative study on mathematical set-based drug release kinetics method and kalman filter method applied in evaluating drug release of multi-component traditional Chinese medicine preparations |
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| SHEN Lan,ZHAI Yu,MA Shi-yu,LIN Xiao,FENG Yi and RUAN Ke-feng. Comparative study on mathematical set-based drug release kinetics method and kalman filter method applied in evaluating drug release of multi-component traditional Chinese medicine preparations[J]. China Journal of Chinese Materia Medica, 2013, 38(8): 1165-1171 | |
| Authors: | SHEN Lan ZHAI Yu MA Shi-yu LIN Xiao FENG Yi RUAN Ke-feng |
| Affiliation: | Shanghai School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai 201203, China;Shanghai School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai 201203, China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai 201203, China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai 201203, China |
| Abstract: | |
| Keywords: | traditional Chinese medicine multi-component evaluation method of synchronized drug release mathematical set Kalman filter method |
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