| 中西医结合治疗对蝮蛇咬伤外周血炎性因子水平及临床疗效的研究 |
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| 引用本文： | 方志美,胡国华,何宝祥,尹亦清,吴玲玲,何国产. 中西医结合治疗对蝮蛇咬伤外周血炎性因子水平及临床疗效的研究[J]. 中国中药杂志, 2013, 38(7): 1087-1090 |
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| 作者姓名： | 方志美 胡国华 何宝祥 尹亦清 吴玲玲 何国产 |
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| 作者单位： | 1. 金华职业技术学院医学院,浙江金华,321017
2. 浙江省兰溪永昌街道满塘岗村社区卫生服务站,浙江兰溪,321100 |
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| 基金项目： | 浙江省金华市科技局项目(2008-3-054) |
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| 摘 要： | 目的:探讨中西医结合治疗下蝮蛇咬伤患者外周血炎性因子(hs-PCR,IL-6,TNF-α)水平变化及临床疗效.方法:将98例患者按照入院时间分为西药组32例,中药组32例,中西医结合组35例.西医组用抗蝮蛇毒血清6000U,每天1次静脉滴注,连用5d.中药组用中药抗蝮蛇2号浓煎剂300 mL,每日分2～3次口服,5d为1疗程.中西医结合组即抗蝮蛇毒血清联合中药抗蝮蛇2号(用法同上).所有患者均于治疗前后采集血标本,用ELISA法检测外周血清炎性因子(hs-PCR,IL-6,TNF-α).并选取同期30例健康人群为健康对照组.结果:3组患者治疗前血清炎性因子水平均高于健康组(P＜0.01),治疗后3组患者炎性因子水平均降低,但中西医结合组比单纯中药与西药组明显降低(P＜0.01)；3组治疗后局部症状消退情况:与单纯中医组、西医组在第1天和第3天比中西医结合组局部症状消退情况最为显著(P＜0.05,P＜0.01)；临床总有效率分别是中西医结合组100％,单纯中药组84.37％,单纯西药组65.62％,中西医结合组明显优于单纯中药与西药组(P＜0.01).结论:蝮蛇咬伤患者外周血炎性因子水平明显增高；中西药结合治疗蝮蛇咬伤能明显降低血炎性因子水平,增加临床疗效,比单纯用中药与西药临床疗效显著.
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| 关 键 词： | 炎性因子 抗腹蛇2号 抗蝮蛇毒血清 中西医结合 |
| 收稿时间： | 2012-11-08 |
Study on clinical efficacy of combination of traditional Chinese medicine and western medicine in treatment of pit viper bites and peripheral blood inflammatory factors |
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| FANG Zhi-mei,HU Guo-hu,HE Bao-xiang,YIN Yi-qing,WU Ling-ling and HE Guo-chan. Study on clinical efficacy of combination of traditional Chinese medicine and western medicine in treatment of pit viper bites and peripheral blood inflammatory factors[J]. China Journal of Chinese Materia Medica, 2013, 38(7): 1087-1090 |
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| Authors: | FANG Zhi-mei HU Guo-hu HE Bao-xiang YIN Yi-qing WU Ling-ling HE Guo-chan |
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| Affiliation: | School of Medicine, Jinhua Polytechnic College, Jinhua 321017, China;School of Medicine, Jinhua Polytechnic College, Jinhua 321017, China;Health Station, Mantanggang Village Community, Yongchang Street, Lanxi 321100, China;School of Medicine, Jinhua Polytechnic College, Jinhua 321017, China;School of Medicine, Jinhua Polytechnic College, Jinhua 321017, China;School of Medicine, Jinhua Polytechnic College, Jinhua 321017, China;Health Station, Mantanggang Village Community, Yongchang Street, Lanxi 321100, China |
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| Abstract: | |
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| Keywords: | inflammatory factor anti pit viper No.2 concentrated decoction antivenom serum combination of traditional Chinese medicine and western medicine |
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