抑癌基因PTEN在涎腺癌组织中的表达

目的:研究PTEN在正常涎腺组织及涎腺癌中的表达及意义。方法:应用免疫组化S鄄P法分别检测8例正常涎腺组织,24例粘液表皮样癌,26例腺样囊性癌中PTEN蛋白的表达。结果:PTEN蛋白在正常涎腺组织及涎腺癌中表达率分别为87.5%、22%,差异有显著性意义(P﹤0.05)。PTEN在高、中分化组粘液表皮样癌高表达率为35.3%,低分化组为28.5%,差异无显著性意义(P>0.05)。腺样囊性癌中PTEN蛋白表达率低于粘液表皮样癌,差异有显著性意义(P﹤0.05)。结论:提示PTEN蛋白与涎腺癌的发生、发展密切相关,PTEN蛋白表达与涎腺癌组织类型有相关性,而与组织学分级无明显相关性。

Expression of Tumor Suppressor Gene PTEN in Salivary Gland Carcinoma

Objective: To study the expression and significance of PTEN in normal salivary gland and salivary gland carcinoma. Methods: The expression of PTEN in 8 normal salivary gland, 24 mucoepidermoid carcinoma, and 26 adenoid cystic carcinoma were detected by immunohistochemical S-P assay. Results: The expression rate of PTEN in normal salivary gland and salivary gland carcinoma were 87.5% and 22% respectively. It was significantly associated with histological grade (P<0.05). Positive rates of PTEN was 35.3% in high and middle-differentiated mucoepidermoid carcinomas, positive rates of PTEN was 28.5% in low-differentiated mucoepidermoid carcinomas. It was not significantly associated with histological grade (P>0.05). The PTEN protein expression rate in adenoid cystic carcinoma was significantly lower than that in mucoepidermoid carcinoma. It was significantly associated with histological grade (P<0.05). Conclusion: PTEN protein plays a key role in the salivary gland carcinoma genesis and development. Expression of PTEN protein is not related to histological grade and is well related to salivary gland carcinoma.